A highly enantioselective four-component reaction for the efficient construction of chiral β-hydroxy-α-amino acid derivatives

被引：34
|
作者：
Qian, Yu [1 ]
Jing, Changcheng [1 ]
Liu, Shunying [1 ]
Hu, Wenhao [1 ]
机构：
[1] E China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 26期
基金：
美国国家科学基金会;
关键词：
MULTICOMPONENT REACTIONS AMCRS; DYNAMIC KINETIC RESOLUTION; BRONSTED ACID; INTRAMOLECULAR CYCLOPROPANATION; COOPERATIVE CATALYSIS; ASYMMETRIC-SYNTHESIS; THREONINE ALDOLASES; DIAZO-COMPOUNDS; ALDEHYDES; HYDROGENATION;
D O I：
10.1039/c3cc40546j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An enantioselective four-component reaction of a diazoketone, water, an aniline and ethyl glyoxylate in the presence of catalytic Rh-2(OAc)(4) and a chiral Bronsted acid was developed to efficiently produce beta-hydroxy-alpha-amino acid derivatives in good yields with high diastereoselectivity and enantioselectivity.
引用
收藏
页码：2700 / 2702
页数：3
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