Physostigmine antagonizes ketamine-induced noradrenaline release from the medial prefrontal cortex in rats

被引：21
|
作者：
Kubota, T [1 ]
Hirota, K [1 ]
Anzawa, N [1 ]
Yoshida, H [1 ]
Kushikata, T [1 ]
Matsuki, A [1 ]
机构：
[1] Hirosaki Univ, Sch Med, Dept Anesthesiol, Hirosaki, Aomori 0368216, Japan
来源：
BRAIN RESEARCH | 1999年 / 840卷 / 1-2期
关键词：
ketamine; physostigmine; medial prefrontal cortex; noradrenaline; rat;
D O I：
10.1016/S0006-8993(99)01793-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Physostigmine is known to antagonize ketamine anesthesia. In this study, effects of physostigmine (0.1 mg kg(-1) i.p.) on ketamine (100 mg kg(-1) i.p.)-induced anesthesia time and noradrenaline release from the medial prefrontal cortex in rats were examined. Ketamine produced anesthesia for 27 +/- 1 min and increased noradrenaline release to 405% of the basal. Physostigmine significantly reduced anesthesia time to 23 +/- 1 min(p < 0.05), and noradrenaline to 248% (p < 0.05). Therefore, noradrenaline release may play an important role in ketamine anesthesia. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：175 / 178
页数：4
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