Immunology of the Uterine and Vaginal Mucosae

被引：71

作者：

Zhou, Jordan Z. ^{[1
,2
,3
,4
]}

Way, Sing Sing ^{[5
,6
]}

Chen, Kang ^{[1
,2
,4
,7
,8
]}

机构：

[1] Wayne State Univ, Dept Obstet, Detroit, MI 48201 USA

[2] Wayne State Univ, Dept Gynecol, Detroit, MI 48201 USA

[3] Wayne State Univ, Ctr Mol Med & Genet, Detroit, MI 48201 USA

[4] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, NIH, Detroit, MI 48201 USA

[5] Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Cincinnati, OH 45229 USA

[6] Cincinnati Childrens Hosp, Perinatal Inst, Cincinnati, OH 45229 USA

[7] Jiangsu Hosp Tradit Chinese Med, Nanjing 210029, Jiangsu, Peoples R China

[8] NIAID, Mucosal Immunol Studies Team, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

来源：

TRENDS IN IMMUNOLOGY | 2018年 / 39卷 / 04期

基金：

美国国家卫生研究院;

关键词：

NATURAL-KILLER-CELLS; LANGERIN(+) DENDRITIC CELLS; REGULATORY T-CELLS; RESIDENT MEMORY; NK CELLS; LANGERHANS CELLS; EXTRAVILLOUS TROPHOBLASTS; POTENTIAL ROLE; DECIDUAL NK; RM CELLS;

D O I：

10.1016/j.it.2018.01.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Along with the maintenance of symbiotic mutualism with commensal microbes and protection against invasive infections common to all mucosal barrier tissues, female reproductive tissues have additional, unique tasks that include dynamic cyclic cellular turnover in menstruation and immunological tolerance to genetically foreign fetal antigens in pregnancy. Here we review current knowledge on distinct features of the immune cells in female reproductive tissue with regard to antimicrobial host defense and adaptations to accommodate the fetus during pregnancy. Outstanding areas for future research to obtain new functional insights on this enigmatic mucosal barrier are also highlighted.

引用

页码：302 / 314

页数：13

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