Evaluation of depression, quality of life and body image in patients with Cushing's disease

被引:27
作者
Alcalar, Nilufer [1 ]
Ozkan, Sedat [1 ]
Kadioglu, Pinar [2 ]
Celik, Ozlem [2 ]
Cagatay, Penbe [3 ]
Kucukyuruk, Baris [4 ]
Gazioglu, Nurperi [4 ]
机构
[1] Istanbul Univ, Istanbul Med Sch, Dept Consultat Liaison Psychiat, TR-34080 Istanbul, Turkey
[2] Istanbul Univ, Cerrahpasa Med Sch, Dept Internal Med, Div Endocrinol & Metab, TR-34080 Istanbul, Turkey
[3] Istanbul Univ, Istanbul Med Sch, Dept Biostat, TR-34080 Istanbul, Turkey
[4] Istanbul Univ, Cerrahpasa Med Sch, Dept Neurosurg, TR-34080 Istanbul, Turkey
关键词
Cushing's disease; Pituitary surgery; Depression; Quality of life; Body image; PSYCHOPATHOLOGY; ADRENALECTOMY; EXPERIENCE; CORTISOL; CURE;
D O I
10.1007/s11102-012-0425-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of this study was to evaluate patients with Cushing's disease (CD) who had undergone transsphenoidal surgery in terms of depression, quality of life (QoL), and perception of body image in comparison to healthy controls. Forty patients with CD and 40 healthy controls matched for demographic characteristics were included in the study. The subjects were evaluated with the Beck depression inventory (BDI), the health survey-short form (SF-36) and the multidimensional body-self relations questionnaire (MBSRQ). Subgroups of the patients with CD were formed on the basis of remission status and BDI scores. In this study, QoL in the general health category and body image were lower in the patients with CD than in the healthy subjects. However, no differences in depression scores were found between the two groups. When the CD group was evaluated according to remission rate, the mean BDI score was significantly higher in the CD patients without remission than in both the CD patients with remission and the healthy subjects (p = 0.04). However, the physical functioning, bodily pain and general health scores of the CD patients without remission on the SF-36 questionnaire were lower than in the CD patients in remission and the healthy subjects (p = 0.002, p = 0.04, p = 0.002, respectively). Fitness evaluation, health evaluation and body areas satisfaction scores of the MBSRQ were significantly different in the three groups (p = 0.003, p = 0.009 and p = 0.001, respectively). In this study, patients with CD were found to have lower QoL, lower body image perception and higher levels of depression compared to healthy controls, particularly if the disease is persistant despite surgery.
引用
收藏
页码:333 / 340
页数:8
相关论文
共 33 条
[1]   The WHO (Ten) well-being index: Validation in diabetes [J].
Bech, P ;
Gudex, C ;
Johansen, KS .
PSYCHOTHERAPY AND PSYCHOSOMATICS, 1996, 65 (04) :183-190
[2]   AN INVENTORY FOR MEASURING DEPRESSION [J].
BECK, AT ;
ERBAUGH, J ;
WARD, CH ;
MOCK, J ;
MENDELSOHN, M .
ARCHIVES OF GENERAL PSYCHIATRY, 1961, 4 (06) :561-&
[3]   Cushing's disease [J].
Bertagna, Xavier ;
Guignat, Laurence ;
Groussin, Lionel ;
Bertherat, Jerome .
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 23 (05) :607-623
[4]   Merits and pitfalls of mifepristone in Cushing's syndrome [J].
Castinetti, F. ;
Fassnacht, M. ;
Johanssen, S. ;
Terzolo, M. ;
Bouchard, P. ;
Chanson, P. ;
Do Cao, C. ;
Morange, I. ;
Pico, A. ;
Ouzounian, S. ;
Young, J. ;
Hahner, S. ;
Brue, T. ;
Allolio, B. ;
Conte-Devolx, B. .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2009, 160 (06) :1003-1010
[5]   CUSHINGS-SYNDROME - PSYCHIATRIC-STUDY OF 29 PATIENTS [J].
COHEN, SI .
BRITISH JOURNAL OF PSYCHIATRY, 1980, 136 (FEB) :120-124
[6]   The longitudinal course of psychopathology in Cushing's syndrome after correction of hypercortisolism [J].
Dorn, LD ;
Burgess, ES ;
Friedman, TC ;
Dubbert, B ;
Gold, PW ;
Chrousos, GP .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (03) :912-919
[7]   Quality of life after laparoscopic bilateral adrenalectomy for Cushing's disease [J].
Hawn, MT ;
Cook, D ;
Deveney, C ;
Sheppard, BC .
SURGERY, 2002, 132 (06) :1064-1068
[8]   Long-term negative impact on quality of life in patients with successfully treated Cushing's disease [J].
Heald, AH ;
Ghosh, S ;
Bray, S ;
Gibson, C ;
Anderson, SG ;
Buckler, H ;
Fowler, HL .
CLINICAL ENDOCRINOLOGY, 2004, 61 (04) :458-465
[9]   Long-term results after microsurgery for Cushing disease:: experience with 426 primary operations over 35 years [J].
Hofmann, Bernd Markus ;
Hlavac, Michal ;
Martinez, Ramon ;
Buchfelder, Michael ;
Mueller, Otto Albrecht ;
Fahlbusch, Rudolf .
JOURNAL OF NEUROSURGERY, 2008, 108 (01) :9-18
[10]  
JEFFCOATE WJ, 1979, Q J MED, V48, P465