Palladium-Catalyzed Oxidative Cycloaddition through C-H/N-H Activation: Access to Benzazepines

被引：116

作者：

Wang, Lei ^{[1
]}

Huang, Jiayao ^{[1
]}

Peng, Shiyong ^{[1
]}

Liu, Hui ^{[2
]}

Jiang, Xuefeng ^{[2
]}

Wang, Jian ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] E China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

benzazepine; C-H activation; N-H activation; oxidative cycloaddition; palladium; N BOND FORMATION; ISOQUINOLONE SYNTHESIS; INTERNAL ALKYNES; ATOM ECONOMY; O BOND; FUNCTIONALIZATION; INDOLES; CHEMISTRY; ARYLATION; CLEAVAGE;

D O I：

10.1002/anie.201208076

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rings beget rings: Benzazepines, well-known structural design elements in medicinal chemistry, are readily prepared by a one-pot palladium-catalyzed oxidative cycloaddition of isatins with various alkynes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1768 / 1772

页数：5

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