Palladium-Catalyzed Oxidative Cycloaddition through C-H/N-H Activation: Access to Benzazepines

被引：116
|
作者：
Wang, Lei [1 ]
Huang, Jiayao [1 ]
Peng, Shiyong [1 ]
Liu, Hui [2 ]
Jiang, Xuefeng [2 ]
Wang, Jian [1 ]
机构：
[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
[2] E China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
benzazepine; C-H activation; N-H activation; oxidative cycloaddition; palladium; N BOND FORMATION; ISOQUINOLONE SYNTHESIS; INTERNAL ALKYNES; ATOM ECONOMY; O BOND; FUNCTIONALIZATION; INDOLES; CHEMISTRY; ARYLATION; CLEAVAGE;
D O I：
10.1002/anie.201208076
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Rings beget rings: Benzazepines, well-known structural design elements in medicinal chemistry, are readily prepared by a one-pot palladium-catalyzed oxidative cycloaddition of isatins with various alkynes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1768 / 1772
页数：5
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