Therapeutic Targeting of Long Non-Coding RNAs in Cancer

被引：499

作者：

Arun, Gayatri ^{[1
]}

Diermeier, Sarah D. ^{[1
]}

Spector, David L. ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2018年 / 24卷 / 03期

关键词：

SPINAL MUSCULAR-ATROPHY; TOLL-LIKE-RECEPTORS; CELL-PROLIFERATION; PROSTATE-CANCER; ANTISENSE OLIGONUCLEOTIDES; MESSENGER-RNA; SMALL-MOLECULE; IN-VIVO; GENE REPRESSION; POOR-PROGNOSIS;

D O I：

10.1016/j.molmed.2018.01.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long non-coding RNAs (lncRNAs) represent a significant population of the human transcriptome. Many lncRNAs exhibit cell- and/or tissue/tumor-specific expression, making them excellent candidates for therapeutic applications. In this review we discuss examples of lncRNAs that demonstrate the diversity of their function in various cancer types. We also discuss recent advances in nucleic acid drug development with a focus on oligonucleotide-based therapies as a novel approach to inhibit tumor progression. The increased success rates of nucleic acid therapeutics provide an outstanding opportunity to explore lncRNAs as viable therapeutic targets to combat various aspects of cancer progression.

引用

页码：257 / 277

页数：21

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