The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample

被引：30
作者：
Crawford, F
Town, T
Freeman, M
Schinka, J
Gold, M
Duara, R
Mullan, M
机构：
[1] Univ S Florida, Roskamp Inst, Tampa, FL 33613 USA
[2] Bristol Myers Squibb Co, Princeton, NJ 08543 USA
[3] Univ Miami, Mt Sinai Memory Disorder Clin, Miami, FL 33152 USA
来源：
NEUROSCIENCE LETTERS | 1999年 / 270卷 / 03期
关键词：
Alzheimer's disease; alpha-2; macroglobulin; genetic association; beta-amyloid;
D O I：
10.1016/S0304-3940(99)00470-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Genetic association has recently been reported between alleles in the alpha-2-macroglobulin (A2M) gene and the occurrence of Alzheimer's disease (AD) in fami I ia I and sporadic samples. We have investigated the A2M intronic deletion polymorphism in a case-control study of 295 unrelated clinic and community-based AD cases, and compared these to a sample of 113 unrelated control individuals recruited as part of an epidemiological study. Our results show no association between A2M and AD in either case sample. Furthermore, A2M is not predictive of AD in an interactive fashion when considering APOE, race or gender, in a subset of our larger sample we have also investigated the A2M Val1000Ile polymorphism, and again find no evidence for association. We conclude that there is no genetic association between A2M and AD in our case-control sample. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：133 / 136
页数：4
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