Prevalence and Clinical Impact of Anaplasia in Childhood Rhabdomyosarcoma A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group

被引:50
作者
Qualman, Stephen [2 ]
Lynch, James [3 ]
Bridge, Julia [4 ]
Parham, David [5 ]
Teot, Lisa [6 ]
Meyer, William [5 ]
Pappo, Alberto [1 ]
机构
[1] Texas Childrens Canc Ctr, Houston, TX 77030 USA
[2] Ctr Childhood Canc, Columbus, OH USA
[3] Univ Nebraska, Coll Publ Hlth, Omaha, NE 68182 USA
[4] Univ Nebraska, Med Ctr, Omaha, NE USA
[5] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA
[6] Univ Pittsburgh, Pittsburgh, PA USA
关键词
rhabdomyosarcoma; anaplasia; soft tissue sarcoma; prognostic significance; incidence;
D O I
10.1002/cncr.23929
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND. Anapalsia is rare in childhood rhabdomyosarcoma and has not been included in the International Classification of Rhabdomyosarcoma (ICR). A recent review of cases from the Soft Tissue Sarcoma Committee of the Children's Oncology Group (COG) suggests that anaplasia might be more common than previously reported and may impact clinical outcome. METHODS. The prevalence of anaplasia (focal or diffuse) was prospectively assessed in 546 eligible cases who were registered in an Intergroup Rhabdomyosarcoma Study Group (IRSG) or COG therapeutic trial from 1995 through 1998. The incidence of anaplasia in tumor samples and its impact in predicting clinical outcome was assessed. RESULTS. Overall, 71 (13%) of all samples analyzed had anaplasia. Anaplasia was more common in patients with tumors in favorable sites and was less commonly observed in younger patients and in those with stage II, III, or clinical group III disease. Regardless of its distribution (focal or diffuse), on univariate analysis the presence of anaplasia negatively influenced the failure-free survival rate (63% vs 77% at 5 years) and overall survival (68% vs 82% at 5 years) rates in patients with embryonal rhabdomyosarcoma. This effect was most pronounced in children with intermediate-risk tumors. Anaplasia did not affect outcome in patients with alveolar tumors. CONCLUSIONS. The incidence of anaplasia in patients with rhabdomyosarcoma is higher than previously described and may be of prognostic significance in children with intermediate-risk embryonal rhabdomyosarcoma. Cancer 2008;113: 3242-7. (C) 2008 American Cancer Society.
引用
收藏
页码:3242 / 3247
页数:6
相关论文
共 32 条
[1]  
[Anonymous], 1983, P ASCO
[2]   ANAPLASTIC WILMS-TUMOR, A SUBTYPE DISPLAYING POOR-PROGNOSIS, HARBORS P53 GENE-MUTATIONS [J].
BARDEESY, N ;
FALKOFF, D ;
PETRUZZI, MJ ;
NOWAK, N ;
ZABEL, B ;
ADAM, M ;
AGUIAR, MC ;
GRUNDY, P ;
SHOWS, T ;
PELLETIER, J .
NATURE GENETICS, 1994, 7 (01) :91-97
[3]   Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes [J].
Bridge, JA ;
Liu, J ;
Qualman, SJ ;
Suijkerbuijk, R ;
Wenger, G ;
Zhang, J ;
Wan, XY ;
Baker, KS ;
Sorensen, P ;
Barr, FG .
GENES CHROMOSOMES & CANCER, 2002, 33 (03) :310-321
[4]   p53 family members in myogenic differentiation and rhabdomyosarcoma development [J].
Cam, Hakan ;
Griesmann, Heidi ;
Beitzinger, Michaela ;
Hofmann, Lars ;
Beinoraviciute-Kellner, Rasa ;
Sauer, Markus ;
Huettinger-Kirchhof, Nicole ;
Oswald, Claudia ;
Friedl, Peter ;
Gattenloehner, Stefan ;
Burek, Christof ;
Rosenwald, Andreas ;
Stiewe, Thorsten .
CANCER CELL, 2006, 10 (04) :281-293
[5]  
COX DR, 1972, J R STAT SOC B, V34, P187
[6]   THE THIRD INTERGROUP RHABDOMYOSARCOMA STUDY [J].
CRIST, W ;
GEHAN, EA ;
RAGAB, AH ;
DICKMAN, PS ;
DONALDSON, SS ;
FRYER, C ;
HAMMOND, D ;
HAYS, DM ;
HERRMANN, J ;
HEYN, R ;
JONES, PM ;
LAWRENCE, W ;
NEWTON, W ;
ORTEGA, J ;
RANEY, RB ;
RUYMANN, FB ;
TEFFT, M ;
WEBBER, B ;
WIENER, E ;
WHARAM, M ;
VIETTI, TJ ;
MAURER, HM .
JOURNAL OF CLINICAL ONCOLOGY, 1995, 13 (03) :610-630
[7]   Intergroup rhabdomyosarcoma study-IV: Results for patients with nonmetastatic disease [J].
Crist, WM ;
Anderson, JR ;
Meza, JL ;
Fryer, C ;
Raney, RB ;
Ruymann, FB ;
Breneman, J ;
Qualman, SJ ;
Wiener, E ;
Wharam, M ;
Lobe, T ;
Webber, B ;
Maurer, HM ;
Donaldson, SS .
JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (12) :3091-3102
[8]   Treatment of anaplastic histology Wilms' tumor: Results from the fifth National Wilms' Tumor Study [J].
Dome, Jeffrey S. ;
Cotton, Cecilia A. ;
Perlman, Elizabeth J. ;
Breslow, Norman E. ;
Kalapurakal, John A. ;
Ritchey, Michael L. ;
Grundy, Paul E. ;
Malogolowkin, Marcio ;
Beckwith, J. Bruce ;
Shamberger, Robert C. ;
Haase, Gerald M. ;
Coppes, Max J. ;
Coccia, Peter ;
Kletzel, Morris ;
Weetman, Robert M. ;
Donaldson, Milton ;
Macklis, Roger M. ;
Green, Daniel M. .
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (15) :2352-2358
[9]   Histopathologic grading of medulloblastomas - A pediatric oncology group study [J].
Eberhart, CG ;
Kepner, JL ;
Goldthwaite, PT ;
Kun, LE ;
Duffner, PK ;
Friedman, HS ;
Strother, DR ;
Burger, PC .
CANCER, 2002, 94 (02) :552-560
[10]   Focal versus diffuse anaplasia in wilms tumor - New definitions with prognostic significance - A report from the National Wilms Tumor Study Group [J].
Faria, P ;
Beckwith, JB ;
Mishra, K ;
Zuppan, C ;
Weeks, DA ;
Breslow, N ;
Green, DM .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (08) :909-920