Xanthine oxidase inhibitors from the flowers of Chrysanthemum sinense

被引：96

作者：

Nguyen, MTT

Awale, S

Tezuka, Y

Ueda, JY

Le Tran, Q

Kadota, S

机构：

[1] Toyama Med & Pharmaceut Univ, Inst Nat Med, Toyama 9300194, Japan

[2] Natl Univ Hochiminh City, Ho Chi Minh City, Vietnam

来源：

PLANTA MEDICA | 2006年 / 72卷 / 01期

关键词：

Chrysanthemum sinense; Asteraceae; acacetin 7-O-(3-O-acetyl-beta-D-glucopyranoside); flavonoids; caffeoylquinic acid; phenolics; Xanthine oxidase inhibition;

D O I：

10.1055/s-2005-873181

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the MeCH extract of the flowers of Chrysanthemum sinense, a new flavone glucoside, acacetin 7-O-(3-O-acetyl-beta-D-glucopyranoside) (1), has been isolated together with 27 known compounds including flavonoids, caffeoylquinic acid derivatives, phenolics, and a monoterpenoid glucoside. Their structures were elucidated on the basis of spectroscopic data. Compounds 1 - 15, 20 - 24, and 27 displayed significant xanthine oxidase inhibitory activity in a concentration-dependent manner, and compounds 2-11 and 22 showed more potent inhibitory activity, with IC50 values ranging from 0.13 to 2.31 mu M, than that of a positive control allopurinol (IC50 = 2.50 mu M). The kinetic study indicated that 1 - 15 and 20 - 24 displayed competitive-type inhibition like that of allopurinol, while 27 displayed a mixed-type inhibition.

引用

页码：46 / 51

页数：6

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