Alzheimer's disease: The use of contrast agents for magnetic resonance imaging to detect amyloid beta peptide inside the brain

被引：32

作者：

Salerno, Milena ^{[1
]}

Porqueras, Diego Santo Domingo ^{[1
]}

机构：

[1] Univ Paris 13, Sorbonne Paris Cite, Lab CSPBAT, CNRS,UFR,SMBH,UMR 7244, 74 Rue Marcel Cachin, F-93017 Bobigny, France

来源：

COORDINATION CHEMISTRY REVIEWS | 2016年 / 327卷

关键词：

Alzheimer's disease; Amyloid beta peptide; Blood brain barrier; Contrast agent; Magnetic resonance imaging; IRON-OXIDE NANOPARTICLES; POSITRON-EMISSION-TOMOGRAPHY; IN-VIVO VISUALIZATION; PITTSBURGH COMPOUND B; A-BETA; TRANSGENIC MICE; EARLY-DIAGNOSIS; NEURITIC PLAQUES; P-GLYCOPROTEIN; MRI DETECTION;

D O I：

10.1016/j.ccr.2016.04.018

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Alzheimer's disease (AD) is a neurodegenerative disease that causes progressive and irreversible loss of mental functions. There is no cure for the disease, which worsens as it progresses, and may lead to death. Amyloid beta peptides (A beta) accumulation in the brain is one of the pathological hallmarks of AD. Together with different clinical examinations, brain imaging techniques are often used to detect A beta plaques inside the brain in order to increase the reliability of the diagnostic of AD. In this review, we compare the use of magnetic resonance imaging (MRI) with other imaging techniques used for A beta detection and present the state of the art concerning the use of contrast agents for MRI proposed for detection of A beta inside the brain. Recent progress in the development of gadolinium complexes and iron oxide nanoparticles as MRI contrast agents targeted toward A beta plaques are discussed. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：27 / 34

页数：8

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