Development of a Cradle-to-Grave Approach for Acetylated Acidic Sophorolipid Biosurfactants

被引：59

作者：

Baccile, Niki ^{[1
]}

Babonneau, Florence ^{[1
]}

Banat, Ibrahim M. ^{[2
]}

Ciesielska, Katarzyna ^{[3
]}

Cuvier, Anne-Sophie ^{[1
]}

Devreese, Bart ^{[3
]}

Everaert, Bernd ^{[4
]}

Lydon, Helen ^{[2
]}

Marchant, Roger ^{[2
]}

Mitchell, Christopher A. ^{[2
]}

Roelants, Sophie ^{[4
,5
]}

Six, Lasse ^{[6
]}

Theeuwes, Elke ^{[7
]}

Tsatsos, Georgios ^{[8
]}

Tsotsou, Georgia Eleni ^{[8
]}

Vanlerberghe, Brecht ^{[4
]}

Van Bogaert, Inge N. A. ^{[5
]}

Soetaert, Wim ^{[4
,5
]}

机构：

[1] UPMC Univ Paris 06, Sorbonne Univ, Chim Mat Condensee Paris, CNRS,Coll France,UMR 7574, F-75005 Paris, France

[2] Univ Ulster, Sch Biomed Sci, Coleraine BT52 1SA, Londonderry, North Ireland

[3] Univ Ghent, Lab Prot Biochem & Biomol Engn, Fac Sci, KL Ledeganckstr 35, B-9000 Ghent, Belgium

[4] Bio Base Europe Pilot Plant, Rodenhuizekaai 1, B-9042 Ghent, Belgium

[5] Univ Ghent, Lab Ind Biotechnolgy & Biocatalysis LnBio Be, Fac Biosci Engn, Coupure Links 653, B-9000 Ghent, Belgium

[6] OWS, Dok Noord 5, B-9000 Ghent, Belgium

[7] Ecover Coordinat Ctr NV, Steenovenstr 1a, B-2390 Malle, Belgium

[8] COSMETIC SP, Ioannou Metaxa 56, Karellas 19400, Koropi, Greece

来源：

ACS SUSTAINABLE CHEMISTRY & ENGINEERING | 2017年 / 5卷 / 01期

关键词：

Starmerella bombicola; Glycolipids; Self-assembly; Life cycle analysis; Antimicrobial; Genetic engineering; THERAPEUTIC APPLICATIONS; PSEUDOMONAS-AERUGINOSA; MICROBIAL-PRODUCTION; GENE; MICELLES;

D O I：

10.1021/acssuschemeng.6b02570

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microbial production of biosurfactants represents one of the most interesting alternatives to classical petrol-based compounds due to their low toxicity, high biodegradability, and biological production processes from renewable bioresources. However, some of the main drawbacks generally encountered are the low productivities and the small number of chemical structures available, which limit widespread application of biosurfactants. Although chemical derivatization of (microbial) biosurfactants offers opportunities to broaden the panel of available molecules, direct microbial synthesis is still the preferred option and the use of engineered strains is becoming a valid alternative. In this multidisciplinary work we show the entire process of conception, upscaling of fermentation (150 L) and sustainable purification (filtration), application (foaming, solubilization, antibacterial), and life cycle analysis of acetylated acidic sophorolipids, directly produced by the starmerella bombicola esterase knock out yeast strain, rather than purified using chromatography from the classical, but complex, mixture of acidic and lactonic sophorolipids.

引用

页码：1186 / 1198

页数：13

共 46 条

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