HDAC6 at the Intersection of Neuroprotection and Neurodegeneration

被引：66

作者：

d'Ydewalle, Constantin ^{[1
,2
]}

Bogaert, Elke ^{[1
,2
]}

Van Den Bosch, Ludo ^{[1
,2
]}

机构：

[1] VIB, Vesalius Res Ctr, Louvain, Belgium

[2] Katholieke Univ Leuven, Lab Neurobiol, Louvain, Belgium

来源：

TRAFFIC | 2012年 / 13卷 / 06期

关键词：

autophagy; axonal transport; deacetylation; HDAC6; microtubules; neurodegeneration; post-translational modifications; HISTONE DEACETYLASE 6; MARIE-TOOTH-DISEASE; GROWTH-FACTOR VEGF; AXONAL-TRANSPORT; ALPHA-SYNUCLEIN; MOUSE MODEL; ACETYLATION; PROTEIN; DEGRADATION; MUTATIONS;

D O I：

10.1111/j.1600-0854.2012.01347.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Histone deacetylase 6 (HDAC6) catalyzes multiple reactions. We summarize the current knowledge on HDAC6, its targets and functions. Among others, HDAC6 recognizes damaged proteins and assures that these proteins are destroyed by autophagy. On the other hand, HDAC6 also modifies the tracks used by the clearance mechanism so that axonal transport becomes less efficient. We hypothesize that a disturbance in the equilibrium between the different functions of HDAC6 could play an important role in neurodegeneration.

引用

页码：771 / 779

页数：9

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