Asymmetric Cascade Carbonylation/Annulation of Benzyl Bromides, CO, and Vinyl Benzoxazinanones Enabled by Pd/Chiral Lewis-Base Relay Catalysis

被引：15

作者：

Ding, Wei-Wei ^{[1
]}

Zhou, Yu ^{[1
]}

Han, Zhi-Yong ^{[1
]}

Gong, Liu-Zhu ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 88卷 / 08期

关键词：

KINETIC RESOLUTION; CHEMISTRY; KETENE; ACID;

D O I：

10.1021/acs.joc.2c02208

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly enantioselective cascade carbonylation/annulation of benzyl bromides, CO, and vinyl benzoxazinanones under mild conditions has been established by Pd/chiral Lewis base relay catalysis, providing an efficient method to assemble chiral quinolinones from readily available starting materials in good yields with excellent diastereo-and enantioselectivities. The palladium catalyst plays two roles in this reaction, enabling both the carbonylation process and the generation of the zwitterionic pi-allyl palladium intermediate.

引用

页码：5187 / 5193

页数：7

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