Acanthamoeba Keratitis in South India: A Longitudinal Analysis of Epidemics

被引：27

作者：

Lalitha, Prajna ^{[4
]}

Lin, Charles C. ^{[1
,2
]}

Srinivasan, Muthiah ^{[4
]}

Mascarenhas, Jeena ^{[4
]}

Prajna, N. Venkatesh ^{[4
]}

Keenan, Jeremy D. ^{[1
,2
]}

McLeod, Stephen D. ^{[1
,2
]}

Acharya, Nisha R. ^{[1
,2
]}

Lietman, Thomas M. ^{[1
,2
,3
]}

Porco, Travis C. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Francis I Proctor Fdn, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[4] Aravind Eye Inst, Madurai, Tamil Nadu, India

来源：

OPHTHALMIC EPIDEMIOLOGY | 2012年 / 19卷 / 02期

关键词：

Acanthamoeba; Cornea; Epidemic; India; Keratitis; CONTACT-LENS SOLUTION; CORNEAL ULCERATION; DIAGNOSIS; OUTBREAK; ENGLAND; TRENDS;

D O I：

10.3109/09286586.2011.645990

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: In light of the increased incidence of contact lens associated Acanthamoeba keratitis in recent years, this study analyzed longitudinal trends of its incidence among predominantly non-contact lens wearers in a high-volume referral center in South India. Methods: A retrospective analysis of microbiology laboratory records at the Aravind Eye Hospital from 1988-2009 was performed. The Maximum Excess Events Test (MEET) was used to identify epidemics of Acanthamoeba keratitis. Results: There were a total of 38,529 unique cases of infectious keratitis evaluated over this time period, of which 372 were culture-positive for Acanthamoeba. Only three cases (0.9%) of Acanthamoeba keratitis occurred among contact lens wearers. MEET identified unique Acanthamoeba keratitis epidemics in 1993 and 2002. Conclusion: Discrete epidemics of Acanthamoeba keratitis occurred among a rural, non-contact lens wearing, population in South India in 1993 and 2002.

引用

页码：111 / 115

页数：5

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