pocrm: An R-package for Phase I trials of combinations of agents

被引：16

作者：

Wages, Nolan A. ^{[1
]}

Varhegyi, Nikole ^{[1
]}

机构：

[1] Univ Virginia, Dept Publ Hlth Sci, Div Translat Res & Appl Stat, Charlottesville, VA 22908 USA

来源：

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE | 2013年 / 112卷 / 01期

关键词：

Continual reassessment method; Dose finding; Phase I trials; Partial ordering; Drug combination; CONTINUAL REASSESSMENT METHOD;

D O I：

10.1016/j.cmpb.2013.05.020

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

This paper presents the R package pocrm for implementing and simulating the partial order continual reassessment method (PO-CRM; [1,2]) in Phase I trials of combinations of agents. The aim of this article is to illustrate, through examples of the pocrm package, how the PO-CRM works and how its operating characteristics can inform clinical trial investigators. This should promote the use of the PO-CRM in designing and conducting dose-finding Phase I trials of combinations of agents. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：211 / 218

页数：8

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