Hallmarks of pluripotency

被引：297

作者：

De Los Angeles, Alejandro ^{[1
,2
,3
,4
,5
]}

Ferrari, Francesco ^{[6
]}

Xi, Ruibin ^{[6
,7
,8
]}

Fujiwara, Yuko ^{[1
,2
,3
,4
,5
]}

Benvenisty, Nissim ^{[9
]}

Deng, Hongkui ^{[10
,11
]}

Hochedlinger, Konrad ^{[4
,5
,6
,12
,13
]}

Jaenisch, Rudolf ^{[14
]}

Lee, Soohyun ^{[6
]}

Leitch, Harry G. ^{[15
]}

Lensch, M. William ^{[1
,2
,3
,4
,5
]}

Lujan, Ernesto ^{[16
]}

Pei, Duanqing ^{[17
]}

Rossant, Janet ^{[18
]}

Wernig, Marius ^{[16
]}

Park, Peter J. ^{[6
]}

Daley, George Q. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Childrens Hosp Boston, Div Pediat Hematol Oncol, Stem Cell Transplantat Program, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[4] Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[5] Howard Hughes Med Inst, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Dept Biomed Informat, Boston, MA 02115 USA

[7] Peking Univ, Sch Math Sci, Beijing 100871, Peoples R China

[8] Peking Univ, Ctr Stat Sci, Beijing 100871, Peoples R China

[9] Hebrew Univ Jerusalem, Inst Life Sci, Dept Genet, Stem Cell Unit, IL-91904 Jerusalem, Israel

[10] Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China

[11] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

[12] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[13] Ctr Regenerat Med, Boston, MA 02114 USA

[14] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[15] Univ London Imperial Coll Sci Technol & Med, MRC, Ctr Clin Sci, London W12 0NN, England

[16] Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

[17] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, South China Inst Stem Cell Biol & Regenerat Med, Guangzhou 510530, Guangdong, Peoples R China

[18] Hosp Sick Children, Res Inst, Toronto, ON M5G 0A4, Canada

来源：

NATURE | 2015年 / 525卷 / 7570期

关键词：

EMBRYONIC STEM-CELLS; X-CHROMOSOME INACTIVATION; PRIMORDIAL GERM-CELLS; GROUND-STATE; DNA METHYLATION; TRANSCRIPTIONAL NETWORK; REGULATORY CIRCUITRY; ISOLATED BLASTOMERES; MOUSE EPIBLAST; SOMATIC-CELLS;

D O I：

10.1038/nature15515

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stem cells self-renew and generate specialized progeny through differentiation, but vary in the range of cells and tissues they generate, a property called developmental potency. Pluripotent stem cells produce all cells of an organism, while multipotent or unipotent stem cells regenerate only specific lineages or tissues. Defining stem-cell potency relies upon functional assays and diagnostic transcriptional, epigenetic and metabolic states. Here we describe functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance.

引用

页码：469 / 478

页数：10

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