Short-Term Effects and Safety Analysis of Retrograde Autologous Blood Priming for Cardiopulmonary Bypass in Patients with Cardiac Valve Replacement Surgery

被引：13

作者：

Cheng, Ming ^{[1
]}

Li, Jun-Quan ^{[1
]}

Wu, Tian-Chi ^{[1
]}

Tian, Wei-Chen ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Cardiac Surg, Harbin 150086, Heilongjiang, Peoples R China

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2015年 / 73卷 / 02期

关键词：

Retrograde autologous blood priming; Cardiopulmonary bypass; Cardiac valve replacement surgery; Valvular heart disease; CONTROLLED-TRIAL; HEART-DISEASE; DOUBLE-BLIND; CIRCUIT; TRANSFUSION; ASSOCIATION; DYSFUNCTION; MANAGEMENT; MORTALITY; INFANTS;

D O I：

10.1007/s12013-015-0661-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This randomized, double-blind study evaluated the short-term effects and safety of perioperative retrograde autologous priming (RAP) for cardiopulmonary bypass (CPB) in patients with cardiac replacement surgery to determine if this approach is a better substitute for crystal liquids priming in patients with valvular heart disease. We observed that RAP significantly decreased the actual priming volume, preserved the hematocrit and hemoglobin level during CPB to a certain degree, and decreased lactate accumulation in CPB period. Moreover, RAP lowered the volume of transfusion and dosage blood products. Thus, our results showed that RAP approach effectively improved tissue perfusion and lowered intraoperative Lac levels, by reducing the hemodilution, which safely and reliably improve the microcirculation perfusion.

引用

页码：441 / 446

页数：6