Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins

被引：41

作者：

Fruchey, Erin R. ^{[1
]}

Monks, Brendan M. ^{[1
]}

Patterson, Andrea M. ^{[1
]}

Cook, Silas P. ^{[1
]}

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 17期

基金：

美国国家科学基金会;

关键词：

CROSS-COUPLING REACTIONS; ALKENYL HALIDES; RADICALS; CYCLIZATION; IODIDES; COMPLEXES; LIGANDS; STEREOCHEMISTRY; MECHANISM; BONDS;

D O I：

10.1021/ol4018694

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new route to trisubstituted olefins through a palladium-catalyzed alkyne insertion/reduction reaction with unactivated alkyl iodides is reported. The reaction proceeds under mild conditions and tolerates a range of functional groups and substitution patterns. Preliminary mechanistic inquiry suggests that the transformation may proceed through a hybrid radical/organometallic pathway.

引用

收藏

页码：4362 / 4365

页数：4

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