A comparison of long term renal functional outcomes following partial nephrectomy and radiofrequency ablation

被引:1
作者
Faddegon, Stephen [1 ]
Ju, Tom [1 ]
Olweny, Ephrem O. [1 ]
Liu, Zhuowei [1 ]
Han, Woong K. [1 ]
Yin, Gang [1 ]
Tan, Yung K. [1 ]
Gahan, Jeffrey [1 ]
Bedir, Selahattin [1 ]
Ma, Yun-Bo [1 ]
Park, Samuel K. [1 ]
Raj, Ganesh V. [1 ]
Cadeddu, Jeffrey A. [1 ]
机构
[1] Univ Texas SW Med Ctr Dallas, Dept Urol, Dallas, TX 75390 USA
关键词
radiofrequency ablation; partial nephrectomy; renal function; glomerular filtration rate; long term; CHRONIC KIDNEY-DISEASE; CORTICAL TUMORS; CELL CARCINOMA; RISK; INSUFFICIENCY; SURGERY; CANCER;
D O I
暂无
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Introduction: To comp are long term glomerular filtration rate (GFR) outcomes of partial nephrectomy and radiofrequency ablation performed for renal malignancy. Materials and methods: Renal function of 347 patients undergoing radiofrequency ablation (n = 142) or partial nephrectomy (n = 205) for renal malignancy between 1994 and 2011 were compared from a retrospective database at a single tertiary care center. Minimum 1 year of follow up was required, resulting in a mean follow up of 48.2 (SD +/- 28.2) months. Renal function was estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The primary study outcome was progression of Chronic Kidney Disease (CKD) stage, calculated using the Kaplan-Meier life table method. Multivariate analysis was also conducted to determine the level of association between GFR decline and treatment modality. Results: The 5 year freedom from CKD stage progression for radiofrequency ablation and partial nephrectomy was 85.4% (95% CI 76.8%-91.1%) versus 82.1% (95% CI 73.7%-88.1%) (p = 0.06). A longer follow up interval was associated with greater GFR decline, although hypertension, diabetes, age, and tumor size were not. Conclusion: Radiofrequency ablation provides similar long term renal function preservation benefit as partial nephrectomy.
引用
收藏
页码:6785 / 6789
页数:5
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