Effect of Anthrax Immune Globulin on Response to BioThrax (Anthrax Vaccine Adsorbed) in New Zealand White Rabbits

被引：15
作者：
Malkevich, Nina V. [1 ]
Basu, Subhendu [1 ]
Rudge, Thomas L., Jr. [2 ]
Clement, Kristin H. [2 ]
Chakrabarti, Ajoy C. [1 ]
Aimes, Ronald T. [1 ]
Nabors, Gary S. [1 ]
Skiadopoulos, Mario H. [1 ]
Ionin, Boris [1 ]
机构：
[1] Emergent BioSolut, Gaithersburg, MD USA
[2] Battelle Biomed Res Ctr, West Jefferson, OH USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 11期
基金：
美国国家卫生研究院;
关键词：
INHALATIONAL ANTHRAX; B-CELLS; PASSIVE-IMMUNIZATION; SOMATIC MUTATION; GUINEA-PIGS; ANTIBODY; MODEL; IMMUNOGENICITY; IMMUNOGLOBULIN; REPERTOIRE;
D O I：
10.1128/AAC.00460-13
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Development of anthrax countermeasures that may be used concomitantly in a postexposure setting requires an understanding of the interaction between these products. Anthrax immune globulin intravenous (AIGIV) is a candidate immunotherapeutic that contains neutralizing antibodies against protective antigen (PA), a component of anthrax toxins. We evaluated the interaction between AIGIV and BioThrax (anthrax vaccine adsorbed) in rabbits. While pharmacokinetics of AIGIV were not altered by vaccination, the vaccine-induced immune response was abrogated in AIGIV-treated animals.
引用
收藏
页码：5693 / 5696
页数：4
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