Cilostazol improves cognitive function in patients with mild cognitive impairment: a retrospective analysis

被引:63
作者
Taguchi, Akihiko [1 ]
Takata, Yu [2 ]
Ihara, Masafumi [1 ]
Kasahara, Yukiko [1 ]
Tsuji, Masahiro [1 ]
Nishino, Madoka [2 ]
Stern, David [3 ]
Okada, Masahiro [2 ]
机构
[1] Inst Biomed Res & Innovat, Dept Regenerat Med Res, Kobe, Hyogo 6500047, Japan
[2] Sumotoitsuki Hosp, Dept Neurosurg, Sumoto, Hyogo 6560014, Japan
[3] Univ Tennessee, Execut Deans Off, Memphis, TN USA
关键词
Alzheimer's disease; amyloid beta; antiplatelet drug; cerebral circulation; cilostazol; mild cognitive impairment; PHOSPHODIESTERASE; POPULATION; INHIBITOR; THERAPY; DISEASE;
D O I
10.1111/psyg.12021
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background and purposeCerebral ischemia and accumulation of amyloid (A) are major risk factors for the development of dementia, including vascular dementia and Alzheimer's disease. Cilostazol, an antiplatelet drug, has been shown to improve cerebral circulation and reduce accumulation of A. In this study, the long-term effect of cilostazol on cognitive function was investigated retrospectively. MethodsMedical records at Sumotoitsuki Hospital were surveyed to find all patients treated with cilostazol and evaluated by the Mini-Mental State Examination (MMSE) during at least two visits separated by an interval of more than 6 months. Patients receiving anti-dementia drugs were excluded. Temporal changes in MMSE scores were compared between patients treated with cilostazol (n = 70) and those who ceased administration of this drug (n = 22). The mean follow-up period was 691 days. ResultsDecrease in MMSE score was significantly ameliorated by administration of cilostazol. Subgroup analysis revealed that cilostazol significantly improved MMSE score in patients with mild cognitive impairment, though no significant effect was observed in patients with normal cognitive function or dementia. ConclusionsAlthough there are limitations to such a retrospective study, these results significantly encourage undertaking a prospective cohort study to determine the effect of cilostazol on mild cognitive impairment where no treatments currently exist.
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页码:164 / 169
页数:6
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