Biological evaluation of an imidazole-fused 1,3,5-triazepinone nucleoside and its photochemical generation via a 6-azidopurine modified oligonucleotide

被引：9

作者：

Komodzinski, Krzysztof ^{[1
]}

Lepczynska, Jolanta ^{[1
]}

Ruszkowski, Piotr ^{[2
]}

Milecki, Jan ^{[1
]}

Skalski, Bohdan ^{[1
]}

机构：

[1] Adam Mickiewicz Univ, Fac Chem, PL-61614 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Pharmacol, Fac Pharm, PL-60806 Poznan, Poland

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 29期

关键词：

6-Azidopurine; Oligonucleotide; Anticancer activity; Purine ring expansion photoreaction; 1,3,5-Triazepinone nucleoside; ADENOSINE-DEAMINASE; INHIBITION; PENTOSTATIN; ANALOGS; PURINE; 2'-DEOXYCOFORMYCIN; ANTIMETABOLITES; COFORMYCIN; VIRUS; ASSAY;

D O I：

10.1016/j.tetlet.2013.05.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The antitumor effects of a novel imidazole-fused 1,3,5-triazepinone nucleoside on KB, MCF-7, and HeLa cell lines were studied via a sulforhodamine B (SRB) colorimetric assay. The results show that the growth of three cancer cell lines studied was significantly inhibited. A method for incorporation of this novel 'fat' nucleoside into oligodeoxynucleotides, based on photochemical transformation of 6-azidopurine has been developed. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3781 / 3784

页数：4

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