ChIPs of the β-globin locus:: unraveling gene regulation within an active domain

被引：81
作者：
Bulger, M [1 ]
Sawado, T [1 ]
Schübeler, D [1 ]
Groudine, M [1 ]
机构：
[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 02期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0959-437X(02)00283-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recent studies of beta-globin gene expression have concentrated on the analysis of factor binding and chromatin structure within the endogenous locus. These studies have more precisely defined the extent and nature of the active chromosomal domain and the elements that organize it. Surprisingly, the beta-globin locus control region (LCR), although critical for high-level gene expression, plays little role in the overall architecture of the active locus. Analysis of the effects of targeted deletion of the beta-globin LCR, along with emerging knowledge of the behavior of the erythroid transcription factor NF-E2, leads to a new perspective on factor binding and LCR function.
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收藏
页码：170 / 177
页数：8
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