Development of nanoparticle drug-delivery systems for the inner ear

被引：20
作者：
An, Xiaogang [1 ]
Zha, Dingjun [1 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp, Dept Otolaryngol Head & Neck Surg, 127 Changle Western Rd, Xian 710032, Shaanxi, Peoples R China
来源：
NANOMEDICINE | 2020年 / 15卷 / 20期
基金：
中国国家自然科学基金;
关键词：
blood-labyrinth barrier; hearing loss; inner ear; nanoparticle drug-delivery systems; nanoparticles; ROUND WINDOW MEMBRANE; IRON-OXIDE NANOPARTICLES; MODIFIED SILICA-NANOPARTICLES; OUTER HAIR-CELLS; HEARING-LOSS; PLGA NANOPARTICLES; STRIA VASCULARIS; GENE-THERAPY; MIDDLE-EAR; LIPOSOMAL NANOPARTICLES;
D O I：
10.2217/nnm-2020-0198
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Hearing loss has become the most common sensory nerve disorder worldwide, with no effective treatment strategy. Low-permeability and limited blood supply to the blood-labyrinth barrier limit the effective delivery and efficacy of therapeutic drugs in the inner ear. Nanoparticle (NP)-based drugs have shown benefits of stable controlled release and functional surface modification, and NP-based delivery systems have become a research hotspot. In this review, we discuss the development of new targeted drug-delivery systems based on the biocompatibility and safety of different NPs in the cochlea, as well as the advantages and disadvantages of their prescription methods and approaches. We believe that targeted NP-based drug-delivery systems will be effective treatments for hearing loss.
引用
收藏
页码：1981 / 1993
页数：13
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