The consequences of not having eosinophils

被引:102
作者
Gleich, G. J. [1 ]
Klion, A. D. [2 ]
Lee, J. J. [3 ]
Weller, P. F. [4 ]
机构
[1] Univ Utah, Hlth Sci Ctr, Salt Lake City, UT 84132 USA
[2] NIAID, NIH, Bethesda, MD 20892 USA
[3] Mayo Clin Arizona, Dept Biochem & Mol Biol, Scottsdale, AZ USA
[4] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA
关键词
anti-interleukin; 5; deficiency; eosinophil; thymoma; ALLERGIC PULMONARY INFLAMMATION; TOTAL ABSENCE; GUINEA-PIG; MEPOLIZUMAB; ANTIBODY; PATIENT; ASTHMA; INTERLEUKIN-5; SAFETY; IL-5;
D O I
10.1111/all.12169
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Several lines of evidence suggest that deficiency of eosinophils is not associated with any characteristic abnormality. Patients lacking eosinophils, in the setting of immunodeficiency or as a consequence of IgG-mediated eosinophil precursor destruction, do not display any distinguishing abnormalities related to eosinophil reduction. The observation that eosinophil-deficient mice do not display any distinctive syndrome or failure of their health is evidence that, under ordinary laboratory conditions, the eosinophil does not play a critical role in the well-being of mammals. Observations that monoclonal antibodies to interleukin-5 (IL-5) are well tolerated appear unsurprising in light of these findings. For example, patients with the hypereosinophilic syndrome have received mepolizumab, an anti-IL-5 monoclonal antibody, for as long as 6years and have not developed any characteristic set of adverse events. Safety data for reslizumab, another anti-IL-5 monoclonal antibody, and benralizumab, a monoclonal antibody to the IL-5 receptor -chain, are comparatively limited, especially for benralizumab, although reports of administration of these antibodies to humans suggest that they are well tolerated. Thus, data to the present suggest that reduction of eosinophils appears to have no characteristic ill effects on normal health, and monoclonal antibodies that deplete eosinophils have the potential to be widely employed in the treatment of eosinophil-associated diseases.
引用
收藏
页码:829 / 835
页数:7
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