Endogenous antigen presentation of MHC class II epitopes through non-autophagic pathways

被引:27
作者
Leung, Carol S. K. [1 ]
机构
[1] UCL, Inst Canc, Dept Haematol, London WC1E 6DD, England
来源
FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷
基金
瑞士国家科学基金会;
关键词
antigen presentation; MHC class II molecules; endogenous presentation; intracellular antigens; non-classical pathways; RESTRICTED T-CELLS; SHOCK-PROTEIN; 90; INVARIANT CHAIN; TUMOR-ANTIGEN; PROCESSING PATHWAYS; CROSS-PRESENTATION; PEPTIDE COMPLEXES; DENDRITIC CELLS; IN-VIVO; MOLECULES;
D O I
10.3389/fimmu.2015.00464
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antigenic peptides presented by major histocompatibility complex (MHC) class II molecules are generally derived from exogenous proteins acquired by antigen presenting cells. However, in some circumstances, MHC class II molecules can present intracellular proteins expressed within the antigen-presenting cells. There are several described pathways by which endogenous antigens are degraded and gain access to MHC class II molecules. These include autophagy and other non-autophagic pathways; the latter category includes the MHC class I-like pathways, heat shock protein 90-mediated pathways, and internalization from the plasma membrane. This review will summarize and discuss the non-autophagic pathways.
引用
收藏
页数:4
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