The size matters: regulation of lipid storage by lipid droplet dynamics

被引：73

作者：

Yu, Jinhai ^{[1
]}

Li, Peng ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Life Sci, Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2017年 / 60卷 / 01期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

lipid storage; lipid droplet; TAG synthesis; atypical LD fusion; lipolysis; CONGENITAL GENERALIZED LIPODYSTROPHY; CHAPERONE-MEDIATED AUTOPHAGY; HORMONE-SENSITIVE LIPASE; BROWN ADIPOSE-TISSUE; DE-NOVO LIPOGENESIS; COA SYNTHETASE 3; ENDOPLASMIC-RETICULUM; INSULIN-RESISTANCE; CIDE PROTEINS; ADRENERGIC-RECEPTORS;

D O I：

10.1007/s11427-016-0322-x

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adequate energy storage is essential for sustaining healthy life. Lipid droplet (LD) is the subcellular organelle that stores energy in the form of neutral lipids and releases fatty acids under energy deficient conditions. Energy storage capacity of LDs is primarily dependent on the sizes of LDs. Enlargement and growth of LDs is controlled by two molecular pathways: neutral lipid synthesis and atypical LD fusion. Shrinkage of LDs is mediated by the degradation of neutral lipids under energy demanding conditions and is controlled by neutral cytosolic lipases and lysosomal acidic lipases. In this review, we summarize recent progress regarding the regulatory pathways and molecular mechanisms that control the sizes and the energy storage capacity of LDs.

引用

页码：46 / 56

页数：11

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