Spectroscopic investigation on the inclusion complex formation between amisulpride and γ-cyclodextrin

被引：63
作者：
Negi, Jeetendra Singh [1 ]
Singh, Shivpal [1 ]
机构：
[1] S Bhagwan Singh PG Inst Biomed Sci & Res, Dept Pharmaceut Sci, Dehra Dun 248161, Uttarakhand, India
来源：
CARBOHYDRATE POLYMERS | 2013年 / 92卷 / 02期
关键词：
Amisulpride; Gamma cyclodextrin; Job's plot; Inclusion complex; BETA-CYCLODEXTRIN;
D O I：
10.1016/j.carbpol.2012.11.082
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The purpose of this research was to investigate inclusion complex formation between poorly soluble drug amisulpride (AMI) and gamma-cyclodextrin (gamma-CD). The solubility of AMI was enhanced by formation of inclusion complex of AMI with nano-hydrophobic cavity of gamma-CD. The stoichiometry of inclusion complex was studied by continuous variation Job's plot method and found 1:1. The binding constant was found 1166.65 M-1 by Benesi-Hildebrand plot. The molecular docking of AMI and gamma-CD was done to investigate complexation. The inclusion complex formation was further confirmed by H-1 NMR and FT-IR, DSC and XRD analysis. The solubility of AMI was increased 3.74 times after inclusion complex formation with gamma-CD. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1835 / 1843
页数：9
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