SOX9 Stem-Cell Factor: Clinical and Functional Relevance in Cancer

被引：64

作者：

Aguilar-Medina, Maribel ^{[1
]}

Avendano-Felix, Mariana ^{[1
]}

Lizarraga-Verdugo, Erik ^{[1
]}

Bermudez, Mercedes ^{[1
]}

Geovanni Romero-Quintana, Jose ^{[1
]}

Ramos-Payan, Rosalio ^{[1
]}

Ruiz-Garcia, Erika ^{[2
,3
]}

Lopez-Camarillo, Cesar ^{[4
]}

机构：

[1] Univ Autonoma Sinaloa, Fac Ciencias Quim Biol, Culiacan, Sinaloa, Mexico

[2] Inst Nacl Cancerol, Lab Med Traslac, Mexico City, DF, Mexico

[3] Inst Nacl Cancerol, Dept Tumores Gastrointestinales, Mexico City, DF, Mexico

[4] Univ Autonoma Ciudad Mexico, Posgrad Ciencias Genom, Mexico City, DF, Mexico

来源：

JOURNAL OF ONCOLOGY | 2019年 / 2019卷

关键词：

BETA-CATENIN; EXPRESSION; DIFFERENTIATION; IDENTIFICATION; METASTASIS; CARCINOMA; INTERPLAY; MET;

D O I：

10.1155/2019/6754040

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Transcriptional and epigenetic embryonic programs can be reactivated in cancer cells. As result, a specific subset of undifferentiated cells with stem-cells properties emerges and drives tumorigenesis. Recent findings have shown that ectoderm- and endoderm-derived tissues continue expressing stem-cells related transcription factors of the SOX-family of proteins such as SOX2 and SOX9 which have been implicated in the presence of cancer stem-like cells (CSCs) in tumors. Currently, there is enough evidence suggesting an oncogenic role for SOX9 in different types of human cancers. This review provides a summary of the current knowledge about the involvement of SOX9 in development and progression of cancer. Understanding the functional roles of SOX9 and clinical relevance is crucial for developing novel treatments targeting CSCs in cancer.

引用

页数：16

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