Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder

被引：12
作者：
Wang, Hongyan [1 ,2 ]
Zhang, Yingquan [3 ]
Qiao, Mingqi [1 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Jinan 250355, Shandong, Peoples R China
[2] Taishan Med Univ, Tai An 271000, Shandong, Peoples R China
[3] Taian Hosp Tradit Chinese Med, Tai An 271000, Shandong, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2013年 / 8卷 / 09期
基金：
中国国家自然科学基金;
关键词：
neural regeneration; reviews; depression; mitogen-activated protein kinase; extracellular signal-regulated kinase; cAMP response element-binding protein; brain-derived neurotrophic factor; 5-hydroxytryptamine; grants-supported paper; neuroregeneration; FACTOR VAL66MET POLYMORPHISM; MAJOR DEPRESSION; CAMP-RESPONSE; FACTOR BDNF; FACTOR GENE; ANTIDEPRESSANT TREATMENT; SUICIDE ATTEMPTS; SERUM-LEVELS; CREB; ASSOCIATION;
D O I：
10.3969/j.issn.1673-5374.2013.09.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway plays an important role in the mechanism of action of antidepressant drugs and has dominated recent studies on the pathogenesis of depression. In the present review we summarize the known roles of extracellular signal-regulated kinase, cAMP response element-binding protein and brain-derived neurotrophic factor in the pathogenesis of depression and in the mechanism of action of antidepressant medicines. The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor pathway has potential to be used as a biological index to help diagnose depression, and as such it is considered as an important new target in the treatment of depression.
引用
收藏
页码：843 / 852
页数：10
相关论文
共 65 条
  • [41] Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway
    Peng, Chi-Hsien
    Chiou, Shih-Hwa
    Chen, Shih-Jen
    Chou, Yueh-Ching
    Ku, Hung-Hal
    Cheng, Cheng-Kuo
    Yen, Chlh-Ju
    Tsai, Tung-Hu
    Chang, Yuh-Lih
    Kao, Chun-Lan
    [J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2008, 18 (02) : 128 - 140
  • [42] Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress
    Qi, Xiaoli
    Lin, Wenjuan
    Li, Junfa
    Li, Huanhuan
    Wang, Weiwen
    Wang, Donglin
    Sun, Meng
    [J]. NEUROBIOLOGY OF DISEASE, 2008, 31 (02) : 278 - 285
  • [43] Rajewska-Rager A, 2008, PSYCHIATR POL, V42, P915
  • [44] RETRACTED: n-3 oolyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism (Retracted article. See vol. 23, 2018)
    Rao, J. S.
    Ertley, R. N.
    Lee, H-J
    DeMar, J. C., Jr.
    Arnold, J. T.
    Rapoport, S. I.
    Bazinet, R. P.
    [J]. MOLECULAR PSYCHIATRY, 2007, 12 (01) : 36 - 46
  • [45] Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients
    Sarchiapone, Marco
    Carli, Vladimir
    Roy, Alec
    Iacoviello, Licia
    Cuomo, Chiara
    Latella, Maria Carmela
    di Giannantonio, Massimo
    Janiri, Luigi
    de Gaetano, Monica
    Janal, Malvin N.
    [J]. NEUROPSYCHOBIOLOGY, 2008, 57 (03) : 139 - 145
  • [46] The BDNF Val66Met polymorphism is an independent risk factor for high lethality in suicide attempts of depressed patients
    Schenkel, Laila Cigana
    Segal, Jair
    Becker, Juliana Allebrand
    Manfro, Gisele Gus
    Bianchin, Marino Muxfeldt
    Leistner-Segal, Sandra
    [J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2010, 34 (06) : 940 - 944
  • [47] A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression
    Serretti, Alessandro
    Chiesa, Alberto
    Calati, Raffaella
    Massat, Isabelle
    Linotte, Sylvie
    Kasper, Siegfried
    Lecrubier, Yves
    Antonijevic, Irina
    Forray, Carlos
    Snyder, Lenore
    Bollen, Joseph
    Zohar, Joseph
    De Ronchi, Diana
    Souery, Daniel
    Mendlewicz, Julien
    [J]. JOURNAL OF AFFECTIVE DISORDERS, 2011, 128 (1-2) : 56 - 63
  • [48] Serum brain-derived neurotrophic factor and glucocorticoid receptor levels in lymphocytes as markers of antidepressant response in major depressive patients: A pilot study
    Soledad Rojas, Paulina
    Fritsch, Rosemarie
    Andrea Rojas, Romina
    Jara, Pablo
    Lucy Fiedler, Jenny
    [J]. PSYCHIATRY RESEARCH, 2011, 189 (02) : 239 - 245
  • [49] Association Between C-281A and Val66met Functional Polymorphisms of BDNF Gene and Risk of Recurrent Major Depressive Disorder in Polish Population
    Suchanek, Renata
    Owczarek, Aleksander
    Kowalczyk, Malgorzata
    Kucia, Krzysztof
    Kowalski, Jan
    [J]. JOURNAL OF MOLECULAR NEUROSCIENCE, 2011, 43 (03) : 524 - 530
  • [50] The early non-increase of serum BDNF predicts failure of antidepressant treatment in patients with major depression: A pilot study
    Tadic, Andre
    Wagner, Stefanie
    Schlicht, Konrad Friedrich
    Peetz, Dirk
    Borysenko, Liudmyla
    Dreimueller, Nadine
    Hiemke, Christoph
    Lieb, Klaus
    [J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2011, 35 (02) : 415 - 420
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