Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder

被引：12
作者：
Wang, Hongyan [1 ,2 ]
Zhang, Yingquan [3 ]
Qiao, Mingqi [1 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Jinan 250355, Shandong, Peoples R China
[2] Taishan Med Univ, Tai An 271000, Shandong, Peoples R China
[3] Taian Hosp Tradit Chinese Med, Tai An 271000, Shandong, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2013年 / 8卷 / 09期
基金：
中国国家自然科学基金;
关键词：
neural regeneration; reviews; depression; mitogen-activated protein kinase; extracellular signal-regulated kinase; cAMP response element-binding protein; brain-derived neurotrophic factor; 5-hydroxytryptamine; grants-supported paper; neuroregeneration; FACTOR VAL66MET POLYMORPHISM; MAJOR DEPRESSION; CAMP-RESPONSE; FACTOR BDNF; FACTOR GENE; ANTIDEPRESSANT TREATMENT; SUICIDE ATTEMPTS; SERUM-LEVELS; CREB; ASSOCIATION;
D O I：
10.3969/j.issn.1673-5374.2013.09.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway plays an important role in the mechanism of action of antidepressant drugs and has dominated recent studies on the pathogenesis of depression. In the present review we summarize the known roles of extracellular signal-regulated kinase, cAMP response element-binding protein and brain-derived neurotrophic factor in the pathogenesis of depression and in the mechanism of action of antidepressant medicines. The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor pathway has potential to be used as a biological index to help diagnose depression, and as such it is considered as an important new target in the treatment of depression.
引用
收藏
页码：843 / 852
页数：10
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