Mechanics of airflow in the human nasal airways

被引:210
作者
Doorly, D. J. [1 ]
Taylor, D. J. [1 ,2 ]
Schroter, R. C. [2 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Aeronaut, London SW7 2AZ, England
[2] Univ London Imperial Coll Sci Technol & Med, Dept Bioengn, London SW7 2AZ, England
基金
英国生物技术与生命科学研究理事会;
关键词
Nasal airways; Computational biomechanics; Physiological flows; Particle image velocimetry;
D O I
10.1016/j.resp.2008.07.027
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The mechanics of airflow in the human nasal airways is reviewed, drawing on the findings of experimental and computational model studies. Modelling inevitably requires simplifications and assumptions, particularly given the complexity of the nasal airways. The processes entailed in modelling the nasal airways (from defining the model, to its production and, finally, validating the results) is critically examined, both for physical models and for computational simulations. Uncertainty still surrounds the appropriateness of the various assumptions made in modelling, particularly with regard to the nature of flow. New results are presented in which high-speed particle image velocimetry (PIV) and direct numerical simulation are applied to investigate the development of flow instability in the nasal cavity. These illustrate some of the improved capabilities afforded by technological developments for future model studies. The need for further improvements in characterising airway geometry and flow together with promising new methods are briefly discussed. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:100 / 110
页数:11
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