CPMV-DOX Delivers

被引：114
作者：
Aljabali, Alaa A. A. [4 ]
Shukla, Sourabh [1 ]
Lomonossoff, George P. [4 ]
Steinmetz, Nicole F. [1 ,2 ,3 ]
Evans, David J. [4 ]
机构：
[1] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Dept Mat Sci & Engn, Cleveland, OH 44106 USA
[4] John Innes Ctr, Dept Biol Chem, Norwich NR4 7UH, Norfolk, England
来源：
MOLECULAR PHARMACEUTICS | 2013年 / 10卷 / 01期
基金：
英国生物技术与生命科学研究理事会;
关键词：
Cowpea mosaic virus; doxorubicin; drug delivery; viral nanoparticle; cancer; COWPEA MOSAIC-VIRUS; VIRAL NANOPARTICLES;
D O I：
10.1021/mp3002057
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The plant virus, Cowpea mosaic virus (CPMV), is developed as a carrier of the chemotherapeutic drug doxorubicin (DOX). CPMV-DOX conjugate, in which eighty DOX molecules are covalently bound to external surface carboxylates of the viral nanoparticle (VNP), shows greater cytotoxicity than free DOX toward HeLa cells when administered at low dosage. At higher concentrations, CPMV-DOX cytotoxicity is time-delayed. The CPMV conjugate is targeted to the endolysosomal compartment of the cells, in which the proteinaceous drug carrier is degraded and the drug released. This study is the first demonstrating the utility of CPMV as a drug delivery vehicle.
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收藏
页码：3 / 10
页数：8
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