β-Catenin-Independent Roles of Wnt/LRP6 Signaling

被引：150
作者：
Acebron, Sergio P. [1 ]
Niehrs, Christof [1 ,2 ]
机构：
[1] Heidelberg Univ, Zentrum Mol Biol, Deutsch Krebsforsch Zentrum DKFZ, Div Mol Embryol,ZMBH Alliance, D-69120 Heidelberg, Germany
[2] Inst Mol Biol, D-55128 Mainz, Germany
来源：
TRENDS IN CELL BIOLOGY | 2016年 / 26卷 / 12期
关键词：
GLYCOGEN-SYNTHASE KINASE-3-BETA; WNT RECEPTOR ACTIVATION; DUAL-KINASE MECHANISM; CELL-CYCLE CONTROL; WNT/BETA-CATENIN; COLON-CANCER; C-MYC; CHROMOSOMAL INSTABILITY; PROTEIN STABILIZATION; DESTRUCTION COMPLEX;
D O I：
10.1016/j.tcb.2016.07.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Wnt/LRP6 signaling is best known for the beta-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of beta-catenin and transcription. We review here the molecular mechanisms underlying beta-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology.
引用
收藏
页码：956 / 967
页数：12
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