The Effects of Preoperative 18F-FDG PET/CT in Breast Cancer Patients in Comparison to the Conventional Imaging Study

被引:50
作者
Choi, Young Jin [1 ]
Shin, Young Duck [2 ]
Kang, Yoon Hee [3 ]
Lee, Moon Soo [1 ]
Lee, Min Koo [1 ]
Cho, Byung Sun [1 ]
Kang, Yoon Jung [1 ]
Park, Ju Seung [1 ]
机构
[1] Eulji Univ, Sch Med, Eulji Univ Hosp, Dept Surg, Taejon 302799, South Korea
[2] Chungbuk Natl Univ, Sch Med, Chungbuk Natl Univ Hosp, Dept Anesthesiol, Cheongju, South Korea
[3] Eulji Univ, Sch Med, Eulji Univ Hosp, Dept Nucl Med, Taejon 302799, South Korea
关键词
Breast; Carcinoma; Computed tomography; Diagnostic imaging; Positron-emission tomography; POSITRON-EMISSION-TOMOGRAPHY; FDG-PET; NODE BIOPSY; METASTASES; ENDOMETRIAL; OVARIAN; CT;
D O I
10.4048/jbc.2012.15.4.441
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: There have been recent studies of the F-18-fluorodeoxyglucose positron emission tomography and computed tomography (F-18-FDG PET/CT) in the staging, detection, and follow-up of the breast cancer occurrence and recurrence. There was controversy concerning the use of F-18-FDG PET/CT for staging primary breast cancer. In this study, we investigated the potential effects of F-18-FDG PET/CT in the initial assessment of patients with primary breast cancer. Methods: From January 2008 to December 2009, 154 consecutive biopsy-proven invasive breast cancer patients were enrolled in this study. Patients underwent conventional imaging studies including mammography, breast ultrasonography (USG), and magnetic resonance imaging for local assessment, and plain chest X-ray, liver USG, and bone scan to rule out distant metastasis. All 154 patients underwent F-18-FDG PET/CT in the initial assessment. Results: F-18-FDG PET/CT did not detect primary breast lesions in 16 patients with a sensitivity of 89.6% and detected only 5 multiple lesions (12.5%) out of 40 cases. Histologically confirmed axillary lymph node (LN) metastases were in 51 patients, and the sensitivity and specificity of F-18-FDG PET/CT to detect metastatic axilla were 37.3% and 95.8%, respectively; whereas the corresponding estimates of USG were 41.2% and 93.7%, respectively. Eleven extra-axillary LN metastases were found in eight patients, and seven lesions were detected by F-18-FDG PET/CT only. The sensitivity and specificity of F-18-FDG PET/CT in detecting distant metastasis were 100% and 96.4%, respectively; whereas the sensitivity and specificity of the conventional imaging were 61.5% and 99.2%, respectively. Conclusion: F-18-FDG PET/CT cannot be recommended as a primary diagnostic procedure in breast cancer, but it has the potential to be used as an additional imaging tool for the detection of axillary metastasis, distant metastasis, and extra-axillary LN metastasis. F-18-FDG PET/CT cannot solely replace the conventional diagnostic procedure in primary breast cancer. The best approach may be the combination of different imaging modalities.
引用
收藏
页码:441 / 448
页数:8
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