Epilepsy presenting as AD: Neuroimaging, electroclinical features, and response to treatment

被引：43
作者：
Hogh, P
Smith, SJ
Scahill, RI
Chan, D
Harvey, RJ
Fox, NC
Rossor, MN
机构：
[1] Natl Hosp Neurol & Neurosurg, Dementia Res Grp, Dept Clin Neurophysiol, London WC1N 3BG, England
[2] Inst Neurol, Dept Clin Neurol, Dementia Res Grp, London WC1N 3BG, England
[3] Univ London Imperial Coll Sci Technol & Med, Div Neurosci, London, England
来源：
NEUROLOGY | 2002年 / 58卷 / 02期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1212/WNL.58.2.298
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Three patients with progressive memory impairment initially attributed to AD underwent serial neuropsychometry, MRI, and EEG. Registered serial MRI volumetric analysis showed no loss of whole or regional brain volume. EEG revealed temporal lobe spike activity and antiepileptic treatment was optimized. Memory functions improved with antiepileptic medication in all three patients. The demonstration of temporal lobe spike activity in patients with progressive memory impairment is an indication for a trial of antiepileptic medication.
引用
收藏
页码：298 / 301
页数：4
相关论文
共 10 条
[1]   SELECTIVE COGNITIVE IMPAIRMENT DURING FOCAL AND GENERALIZED EPILEPTIFORM EEG ACTIVITY [J].
AARTS, JHP ;
BINNIE, CD ;
SMIT, AM ;
WILKINS, AJ .
BRAIN, 1984, 107 (MAR) :293-308
[2]   Effect of seizures and epileptiform discharges on cognitive function [J].
Aldenkamp, AP .
EPILEPSIA, 1997, 38 :S52-S55
[3]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[4]   Visualisation and quantification of rates of atrophy in Alzheimer's disease [J].
Fox, NC ;
Freeborough, PA ;
Rossor, MN .
LANCET, 1996, 348 (9020) :94-97
[5]   A multidisciplinary memory clinic in a neurological setting: diagnostic evaluation of 400 consecutive patients [J].
Hogh, P ;
Waldemar, G ;
Knudsen, GM ;
Bruhn, P ;
Mortensen, H ;
Wildschiodtz, G ;
Bech, RA ;
Juhler, M ;
Paulson, OB .
EUROPEAN JOURNAL OF NEUROLOGY, 1999, 6 (03) :279-288
[6]  
MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939
[7]   EPILEPTIC AMNESIC ATTACKS - BENEFIT FROM ANTIEPILEPTIC DRUGS [J].
PRITCHARD, PB ;
HOLMSTROM, VL ;
ROITZSCH, JC ;
GIACINTO, J .
NEUROLOGY, 1985, 35 (08) :1188-1189
[8]   Epileptic pseudodementia [J].
Tatum, WO ;
Ross, J ;
Cole, AJ .
NEUROLOGY, 1998, 50 (05) :1472-1475
[9]  
Walstra GJM, 1997, J NEUROL, V244, P17
[10]   Transient epileptic amnesia: a description of the clinical and neuropsychological features in 10 cases and a review of the literature [J].
Zeman, AZJ ;
Boniface, SJ ;
Hodges, JR .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1998, 64 (04) :435-443
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