Worldwide emergence of multiple clades of enterovirus 68

被引:177
作者
Tokarz, Rafal [1 ]
Firth, Cadhla [1 ]
Madhi, Shabir A. [2 ,3 ]
Howie, Stephen R. C. [4 ]
Wu, Winfred [5 ]
Sall, Amadou Alpha [1 ]
Haq, Saddef [1 ]
Briese, Thomas [1 ]
Lipkin, W. Ian [1 ]
机构
[1] Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY 10032 USA
[2] Natl Inst Communicable Dis, Div Natl Hlth Lab Serv, ZA-2131 Johannesburg, South Africa
[3] Univ Witwatersrand, Dept Sci & Technol, Natl Res Fdn Vaccine Preventable Dis, Johannesburg 2050, South Africa
[4] Child Survival Theme, Med Res Council Unit, Banjul, Gambia
[5] New York City Dept Hlth & Mental Hyg, Gotham Ctr, New York, NY 11101 USA
基金
美国国家卫生研究院;
关键词
INFLUENZA-LIKE ILLNESS; RESPIRATORY-INFECTIONS; CHILDREN; PCR;
D O I
10.1099/vir.0.043935-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Human enterovirus 68 (EV-D68) is a historically rarely reported virus linked with respiratory disease. In the past 3 years, a large increase in respiratory disease associated with EV-D68 has been reported, with documented outbreaks in North America, Europe and Asia. In several outbreaks, genetic differences were identified among the circulating strains, indicating the presence of multiple clades. In this report, we analyse archived and novel EV-D68 strains from Africa and the USA, obtained from patients with respiratory illness. Phylogenetic analysis of all EV-D68 sequences indicates that, over the past two decades, multiple clades of the virus have emerged and spread rapidly worldwide. All clades appear to be currently circulating and contributing to respiratory disease.
引用
收藏
页码:1952 / 1958
页数:7
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