Mutltifaceted biological roles of leptin

被引：6

作者：

Charchour, Rim ^{[1
]}

Dufour-Rainfray, Diane ^{[2
,3
,4
]}

Morineau, Gilles ^{[5
]}

Vatier, Camille ^{[6
,7
]}

Fellahi, Soraya ^{[6
,8
]}

Vigouroux, Corinne ^{[6
,7
,9
]}

Genoux, Annelise ^{[10
]}

Capeau, Jacqueline ^{[6
]}

Lacorte, Jean-Marc ^{[11
,12
]}

Collet, Christine ^{[2
]}

Cuerq, Charlotte ^{[13
,14
,15
]}

Bastard, Jean-Philippe ^{[1
,6
,8
]}

机构：

[1] Hop Univ Henri Mondor, AP HP, Dept Biochim Pharmacol Biol Mol Genet Med, Creteil, France

[2] CHU Tours, Serv Med Nucl In Vitro, Tours, France

[3] Univ Tours, UMR 1253, iBrain, INSERM, Tours, France

[4] Soc Francaise Med Nucl, Grp Biol Specialisee, Paris, France

[5] Hop Lariboisiere, AP HP, Serv Biochim & Biol Mol, Paris, France

[6] Sorbonne Univ, INSERM, UMR S 938, Ctr Rech St Antoine,Inst Hosp Univ Cardiometab &, Paris, France

[7] Hop St Antoine, AP HP, Ctr Natl Reference Pathol Rares Insulino Secret &, Paris, France

[8] Hop Tenon, AP HP, Serv Biochim & Hormonal, UF Biomarquees Inflammatoires & Metabol, Paris, France

[9] Hop St Antoine, AP HP, Lab Commun Biol & Genet Mol, Paris, France

[10] CHU Toulouse, Lab Biochim, Inst Federatif Biol, Toulouse, France

[11] Hop Pitie Salpetriere Charles Foix, AP HP, Serv Biochim Endocrinienne & Oncol, Paris, France

[12] Sorbonne Univ, INSERM, UMR S 1166, Res Inst Cardiovasc Dis Metab & Nutr, Paris, France

[13] Hosp Civils Lyon, Ctr Hosp Lyon Sud, Lab Biochim & Biol Mol, Lyon, France

[14] Unite Med Nutr Endocrinol Metab, Pierre Benite, France

[15] INSERM, U1060, CarMeN, Bron, France

来源：

ANNALES DE BIOLOGIE CLINIQUE | 2020年 / 78卷 / 03期

关键词：

leptin; metabolic syndrome; obesity; cancer; fertility; dementia; FATTY LIVER-DISEASE; EARLY-ONSET OBESITY; BODY-MASS INDEX; CIRCULATING LEPTIN; ADIPOSE-TISSUE; BREAST-CANCER; SERUM LEPTIN; INSULIN-RESISTANCE; METABOLIC SYNDROME; MENSTRUAL-CYCLE;

D O I：

10.1684/abc.2020.1560

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The identification of leptin allowed the discovery of a new endocrine system. This major adipokine controlling energy homeostasis is also involved in the regulation of neuroendocrine function and fertility. Unfortunately, leptin is not able to treat common obesity, which associates hyperleptinemia and resistance to the hormone. Conversely, treatment with recombinant leptin is effective in situations of leptin deficiency. Several pathophysiological situations associated with adipose tissue dysfunctions and abnormal regulation of leptin secretion are discussed in this review. The advantage of the potential use of the leptin assay in some pathophysiological conditions is proposed.

引用

页码：231 / 242

页数：12

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