Oleanolic acid enhances insulin secretion in pancreatic β-cells

被引：97

作者：

Teodoro, Tracy ^{[1
,2
]}

Zhang, Liling ^{[1
]}

Alexander, Todd ^{[3
]}

Yue, Jessica ^{[4
]}

Vranic, Mladen ^{[4
]}

Volchuk, Allen ^{[1
,2
,4
]}

机构：

[1] Univ Hlth Network, Toronto Gen Res Inst, Div Cell & Mol Biol, Toronto, ON M5G 1L7, Canada

[2] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A1, Canada

[3] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[4] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A1, Canada

来源：

FEBS LETTERS | 2008年 / 582卷 / 09期

关键词：

pancreatic beta-cell; insulin secretion; oleanolic acid; insulin biosynthesis;

D O I：

10.1016/j.febslet.2008.03.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effect of oleanolic acid, a plant-derived triterpenoid, on insulin secretion and content in pancreatic beta-cells and rat islets. Oleanolic acid significantly enhanced insulin secretion at basal and stimulatory glucose concentrations in INS-1 832/ 13 cells and enhanced acute glucose-stimulated insulin secretion in isolated rat islets. In the cell line the effects of oleanolic acid on insulin secretion were comparable to that of the sulfonylurea tolbutamide at basal glucose levels and with the incretin mimetic Exendin-4 under glucose-stimulated conditions, yet neither Ca2+ nor cAMP rose in response to oleanolic acid. Chronic treatment with oleanolic acid increased total cellular insulin protein and mRNA levels. These effects may contribute to the anti-diabetic properties of this natural product. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1375 / 1380

页数：6

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