Serum interleukin-16 levels in patients with nasal polyposis

被引：4
作者：
Keseroglu, Kemal
Banoglu, Erden [3 ]
Kizil, Yusuf
Aydil, Utku [1 ]
Gonul, Ipek Isil [2 ]
Yilmaz, Metin
Ceylan, Alper
机构：
[1] Gazi Univ, Tip Fak KBB AD, Dept Otorhinolaryngol, Sch Med, TR-06500 Ankara, Turkey
[2] Gazi Univ, Dept Pathol, Sch Med, TR-06500 Ankara, Turkey
[3] Gazi Univ, Dept Pharmaceut Chem, Sch Pharm, TR-06500 Ankara, Turkey
来源：
LARYNGOSCOPE | 2012年 / 122卷 / 05期
关键词：
Interleukin-16; inflammation; nasal polyposis; eosinophilia; enzyme-linked immunosorbent assay; Level of Evidence: 2b; PROMOTER POLYMORPHISM; CATIONIC PROTEIN; EXPRESSION; IL-16; ASSOCIATION; EOSINOPHILS; EOTAXIN;
D O I：
10.1002/lary.23238
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective/Hypothesis: Several inflammatory and allergic disorders have been reported to correlate with interleukin-16 (IL-16). IL-16 is a highly potent chemotactic and chemoattractant molecule for eosinophils. Nasal polyposis (NP) has an inflammatory basis, and eosinophilia is a common finding in polyp tissue. In this study, we aimed to determine serum IL-16 levels in NP patients. Study Design: Prospective controlled study in a tertiary academic hospital. Methods: Peripheral blood samples were obtained and used for serologic studies with enzyme-linked immunosorbent assay kits to determine IL-16 levels. Results: The study and the control groups consisted of 17 and 10 patients, respectively. Mean serum IL-16 levels were significantly higher in the study group when compared to the control group (447.9 pg/mL vs. 260.2 pg/mL) (P < .001). Conclusions: Serum IL-16 levels are significantly elevated in NP patients. This finding may represent identification of a valuable serum biomarker and potential therapeutic target in NP patients.
引用
收藏
页码：961 / 964
页数：4
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