Combination of probiotics and coccidiosis vaccine enhances protection against an Eimeria challenge

被引:67
作者
Ritzi, Miranda M. [1 ]
Abdelrahman, Wael [2 ]
van-Heerden, Kobus [3 ]
Mohnl, Michaela [4 ]
Barrett, Nathaniel W. [1 ]
Dalloul, Rami A. [1 ]
机构
[1] Virginia Tech, Dept Anim & Poultry Sci, Avian Immunobiol Lab, Blacksburg, VA 24061 USA
[2] Suez Canal Univ, Fac Vet Med, Ismailia, Egypt
[3] Ceva Anim Hlth, Guelph, ON, Canada
[4] BIOMIN Holding GmbH, Herzogenburg, Austria
基金
美国食品与农业研究所;
关键词
GROWTH-PERFORMANCE; ANTICOCCIDIAL VACCINES; BROILER-CHICKENS; IMMUNE-RESPONSE; POULTRY; LACTOBACILLUS; EFFICACY; COLONIZATION; ACERVULINA; SALMONELLA;
D O I
10.1186/s13567-016-0397-y
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Coccidiosis is endemic in the commercial broiler industry capable of inflicting devastating economic losses to poultry operations. Vaccines are relatively effective in controlling the disease; their efficacy could potentially be improved with concurrent use of probiotics as evaluated in this study using an Eimeria challenge. Day of hatch 400 Cobb-500 male broilers were assigned to one of four treatment groups including control (CON), vaccine-only gel application (VNC), probiotic-only gel application (NPC), and vaccine-plus-probiotic gel application (VPC). Birds were placed in floor pens (6 replicate pens/treatment, 16-17 birds/pen). NPC and VPC birds received the probiotics in the water on days 2-4, 8, 14-20, 22, 29, and 34-36. On day 15, birds were mildly challenged with 0.5 mL of a mixed oral inoculum of Eimeria sp. prepared with the coccidiosis vaccine at 10x the vaccination dose. Performance measurements were recorded on first day and weekly afterwards, and lesion scores were evaluated 6 days post-challenge. Overall, the probiotics and coccidiosis vaccine resulted in an enhanced protective effect against the challenge, with VPC birds exhibiting lower lesion scores in the duodenum than VNC or NPC birds. Birds in the VPC treatment also demonstrated higher weight gains during days 1-15, days 7-15, and days 21-28 when compared to the VNC birds. These results suggest that the combination of probiotics and coccidiosis vaccines could enhance performance and provide an additional protective effect against a mixed Eimeria challenge.
引用
收藏
页码:1 / 8
页数:8
相关论文
共 39 条
[1]   Recent advances in biology and immunobiology of Eimeria species and in diagnosis and control of infection with these coccidian parasites of poultry [J].
Allen, PC ;
Fetterer, RH .
CLINICAL MICROBIOLOGY REVIEWS, 2002, 15 (01) :58-+
[2]   Growth performance, nutrient digestibility and immune response of broiler chicks fed diets supplemented with a culture of Lactobacillus bulgaricus [J].
Apata, D. F. .
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2008, 88 (07) :1253-1258
[3]   History of the use of antibiotic as growth promoters in European poultry feeds [J].
Castanon, J. I. R. .
POULTRY SCIENCE, 2007, 86 (11) :2466-2471
[4]   Guidelines for evaluating the efficacy and safety of live anticoccidial vaccines, and obtaining approval for their use in chickens and turkeys [J].
Chapman, HD ;
Roberts, B ;
Shirley, MW ;
Williams, RB .
AVIAN PATHOLOGY, 2005, 34 (04) :279-290
[5]   Sustainable coccidiosis control in poultry production: the role of live vaccines [J].
Chapman, HD ;
Cherry, TE ;
Danforth, HD ;
Richards, G ;
Shirley, MW ;
Williams, RB .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2002, 32 (05) :617-629
[6]   Immunomodulatory role of probiotics in poultry and potential in ovo application [J].
Cox, C. M. ;
Dalloul, R. A. .
BENEFICIAL MICROBES, 2015, 6 (01) :45-52
[7]   Induction of local protective immunity to Eimeria acervulina by a Lactobacillus-based probiotic [J].
Dalloul, RA ;
Lillehoj, HS ;
Tamim, NM ;
Shellem, TA ;
Doerr, JA .
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 2005, 28 (5-6) :351-361
[8]   Recent advances in immunomodulation and vaccination strategies against coccidiosis [J].
Dalloul, RA ;
Lillehoj, HS .
AVIAN DISEASES, 2005, 49 (01) :1-8
[9]   Enhanced mucosal immunity against Eimeria acervulina in broilers fed a Lactobacillus-based probiotic [J].
Dalloul, RA ;
Lillehoj, HS ;
Shellem, TA ;
Doerr, JA .
POULTRY SCIENCE, 2003, 82 (01) :62-66
[10]   Poultry coccidiosis: recent advancements in control measures and vaccine development [J].
Dalloul, Rami A. ;
Lillehoj, Hyun S. .
EXPERT REVIEW OF VACCINES, 2006, 5 (01) :143-163