Mouse Models for Exploring the Biological Consequences and Clinical Significance of PIK3CA Mutations

被引：15

作者：

Mitchell, Camilla B. ^{[1
]}

Phillips, Wayne A. ^{[1
,2
]}

机构：

[1] Peter MacCallum Canc Ctr, Melbourne, Vic 3000, Australia

[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, Australia

来源：

BIOMOLECULES | 2019年 / 9卷 / 04期

基金：

英国医学研究理事会;

关键词：

PI3K; PI; 3-kinase; PIK3CA; mouse model; knock-in; transgenic; cancer; overgrowth; PROS; PHOSPHOINOSITIDE; 3-KINASE; PIK3CA(H1047R) MUTATION; ACTIVATING MUTATIONS; SOMATIC MUTATIONS; PI3K ACTIVATION; MAMMARY-TUMORS; PATHWAY; EXPRESSION; TUMORIGENESIS; RESISTANCE;

D O I：

10.3390/biom9040158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The phosphatidylinositol 3-kinase (PI3K) pathway is involved in a myriad of cellular signalling pathways that regulate cell growth, metabolism, proliferation and survival. As a result, alterations in the PI3K pathway are frequently associated with human cancers. Indeed, PIK3CAthe gene encoding the p110 catalytic subunit of PI3Kis one of the most commonly mutated human oncogenes. PIK3CA mutations have also been implicated in non-malignant conditions including congenital overgrowth syndromes and vascular malformations. In order to study the role of PIK3CA mutations in driving tumorigenesis and tissue overgrowth and to test potential therapeutic interventions for these conditions, model systems are essential. In this review we discuss the various mouse models currently available for preclinical studies into the biological consequences and clinical significance of PIK3CA mutations.

引用

页数：17

共 74 条

[1] Cooperation between Pik3ca and p53 Mutations in Mouse Mammary Tumor Formation [J].

Adams, Jessica R. ;

Xu, Keli ;

Liu, Jeff C. ;

Agamez, Natalia M. Ruiz ;

Loch, Amanda J. ;

Wong, Ruth G. ;

Wang, Wei ;

Wright, Katherine L. ;

Lane, Timothy F. ;

Zacksenhaus, Eldad ;

Egan, Sean E. .

CANCER RESEARCH, 2011, 71 (07) :2706-2717

[2] TRANSGENIC MODELS OF TUMOR-DEVELOPMENT [J].

ADAMS, JM ;

CORY, S .

SCIENCE, 1991, 254 (5035) :1161-1167

[3] Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling [J].

Berenjeno, Inma M. ;

Pineiro, Roberto ;

Castillo, Sandra D. ;

Pearce, Wayne ;

McGranahan, Nicholas ;

Dewhurst, Sally M. ;

Meniel, Valerie ;

Birkbak, Nicolai J. ;

Lau, Evelyn ;

Sansregret, Laurent ;

Morelli, Daniele ;

Kanu, Nnennaya ;

Srinivas, Shankar ;

Graupera, Mariona ;

Parker, Victoria E. R. ;

Montgomery, Karen G. ;

Moniz, Larissa S. ;

Scudamore, Cheryl L. ;

Phillips, Wayne A. ;

Semple, Robert K. ;

Clarke, Alan ;

Swanton, Charles ;

Vanhaesebroeck, Bart .

NATURE COMMUNICATIONS, 2017, 8

[4] Mutation of the PIK3CA gene in ovarian and breast cancer [J].

Campbell, IG ;

Russell, SE ;

Choong, DYH ;

Montgomery, KG ;

Ciavarella, ML ;

Hooi, CSF ;

Cristiano, BE ;

Pearson, RB ;

Phillips, WA .

CANCER RESEARCH, 2004, 64 (21) :7678-7681

[5] Somatic PIK3CA mutations as a driver of sporadic venous malformations [J].

Castel, Pau ;

Carmona, F. Javier ;

Grego-Bessa, Joaquim ;

Berger, Michael F. ;

Viale, Agnes ;

Anderson, Kathryn V. ;

Bague, Silvia ;

Scaltriti, Maurizio ;

Antonescu, Cristina R. ;

Baselga, Eulalia ;

Baselga, Jose .

SCIENCE TRANSLATIONAL MEDICINE, 2016, 8 (332)

[6] Phosphoinositide 3-kinase: a new kid on the block in vascular anomalies [J].

Castillo, Sandra D. ;

Vanhaesebroeck, Bart ;

Sebire, Neil J. .

JOURNAL OF PATHOLOGY, 2016, 240 (04) :387-396

[7] Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans [J].

Castillo, Sandra D. ;

Tzouanacou, Elena ;

Zaw-Thin, May ;

Berenjeno, Inma M. ;

Parker, Victoria E. R. ;

Chivite, Inigo ;

Mila-Guasch, Maria ;

Pearce, Wayne ;

Solomon, Isabelle ;

Angulo-Urarte, Ana ;

Figueiredo, Ana M. ;

Dewhurst, Robert E. ;

Knox, Rachel G. ;

Clark, Graeme R. ;

Scudamore, Cheryl L. ;

Badar, Adam ;

Kalber, Tammy L. ;

Foster, Julie ;

Stuckey, Daniel J. ;

David, Anna L. ;

Phillips, Wayne A. ;

Lythgoe, Mark F. ;

Wilson, Valerie ;

Semple, Robert K. ;

Sebire, Neil J. ;

Kinsler, Veronica A. ;

Graupera, Mariona ;

Vanhaesebroeck, Bart .

SCIENCE TRANSLATIONAL MEDICINE, 2016, 8 (332)

[8] Activating BRAF and PIK3CA Mutations Cooperate to Promote Anaplastic Thyroid Carcinogenesis [J].

Charles, Roch-Philippe ;

Silva, Jillian ;

Iezza, Gioia ;

Phillips, Wayne A. ;

McMahon, Martin .

MOLECULAR CANCER RESEARCH, 2014, 12 (07) :979-986

[9] Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse [J].

Coelho, Paula A. ;

Bury, Leah ;

Shahbazi, Marta N. ;

Liakath-Ali, Kifayathullah ;

Tate, Peri H. ;

Wormald, Sam ;

Hindley, Christopher J. ;

Huch, Meritxell ;

Archer, Joy ;

Skarnes, William C. ;

Zernicka-Goetz, Magdalena ;

Glover, David M. .

OPEN BIOLOGY, 2015, 5 (12)

[10] A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma [J].

Collisson, Eric A. ;

Trejo, Christy L. ;

Silva, Jillian M. ;

Gu, Shenda ;

Korkola, James E. ;

Heiser, Laura M. ;

Charles, Roch-Philippe ;

Rabinovich, Brian A. ;

Hann, Byron ;

Dankort, David ;

Spellman, Paul T. ;

Phillips, Wayne A. ;

Gray, Joe W. ;

McMahon, Martin .

CANCER DISCOVERY, 2012, 2 (08) :685-693

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