CD38 gene polymorphism and risk of chronic lymphocytic leukemia

被引：3

作者：

Abramenko, Iryna V. ^{[1
]}

Bilous, Nadiia I. ^{[1
]}

Pleskach, Gleb V. ^{[1
]}

Chumak, Anatoliy A. ^{[1
]}

Kryachok, Iryna A. ^{[2
]}

Martina, Zoya V. ^{[3
]}

Dyagil, Iryna S. ^{[3
]}

机构：

[1] Natl Acad Med Sci, Natl Res Ctr Radiat Med, Dept Clin Immunol, UA-03115 Kiev, Ukraine

[2] Natl Canc Inst, Kiev, Ukraine

[3] Natl Acad Med Sci, Natl Res Ctr Radiat Med, Dept Hematol, UA-03115 Kiev, Ukraine

来源：

LEUKEMIA RESEARCH | 2012年 / 36卷 / 10期

关键词：

Chronic lymphocytic leukemia; CD38; rs6449182; polymorphism; Genetic susceptibility; CELLS; EXPRESSION;

D O I：

10.1016/j.leukres.2012.05.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

rs6449182 CD38 gene polymorphism was determined by polymerase chain reaction with restriction of products in 328 chronic lymphocytic leukemia (CLL) patients and 271 age-and sex-matched controls. An association between GG genotype and CLL risk was found in the whole group of patients (OR = 2.12; p = 0.009) and in patients with unmutated immunoglobulin heavy chain variable genes (OR = 2.17; p = 0.011) comparing to the controls. In the subgroup of 174 controls with evaluated lipids the genotype distributions in CLL patients and dyslipidemic controls were similar. An association between GG genotype and CLL risk was significant compared to controls without lipids' abnormalities (OR = 3.92; p = 0.006). (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1237 / 1240

页数：4

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