2017 McDonald criteria for multiple sclerosis: Earlier diagnosis with reduced specificity?

被引：30

作者：

Gobbin, Francesca ^{[1
,2
]}

Zanoni, Mattia ^{[1
,2
]}

Marangi, Antonio ^{[1
,2
]}

Orlandi, Riccardo ^{[1
,2
]}

Crestani, Laura ^{[3
]}

Benedetti, Maria Donata ^{[1
,2
]}

Gajofatto, Alberto ^{[1
,2
]}

机构：

[1] Univ Verona, Dept Neurosci Biomed & Movement Sci, Piazzale LA Scuro 10, I-37134 Verona, Italy

[2] Azienda Osped Univ Integrata Verona, Neurol Unit B, Piazzale LA Scuro 10, I-37134 Verona, Italy

[3] GPI SpA, Verona, Italy

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2019年 / 29卷

关键词：

D O I：

10.1016/j.msard.2019.01.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: McDonald criteria for multiple sclerosis (MS) diagnosis were revised in 2017. Objective: Aim of our study was to evaluate and compare the sensitivity and specificity of 2017 and 2010 McDonald criteria in patients presenting with an initial demyelinating event (IDE). Methods: We retrospectively identified patients with an IDE and collected clinical, MRI and CSF data in order to demonstrate fulfilment of 2010 and 2017 McDonald criteria. Results: 2017 McDonald criteria showed 100% (86.8-100%) sensitivity and 13.8% (3.9-31.7%) specificity. Conclusion: 2017 McDonald criteria appear to have higher sensitivity but reduced specificity compared to 2010 McDonald criteria.

引用

页码：23 / 25

页数：3

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