Fronto-limbic volumetric changes in major depressive disorder

被引:56
作者
Malykhin, Nikolai V. [1 ,2 ,3 ]
Carter, Rawle [2 ]
Hegadoren, Kathleen M. [4 ]
Seres, Peter
Coupland, Nicholas J. [2 ]
机构
[1] Univ Alberta, Fac Med & Dent, Dept Biomed Engn, Edmonton, AB T6G 2V2, Canada
[2] Univ Alberta, Dept Psychiat, Edmonton, AB, Canada
[3] Univ Alberta, Ctr Neurosci, Edmonton, AB, Canada
[4] Univ Alberta, Fac Nursing, Edmonton, AB, Canada
基金
加拿大健康研究院;
关键词
Major depression; Limbic system; Amygdala; Cingulate gyrus; Prefrontal cortex; Volumetric MRI; SUBGENUAL PREFRONTAL CORTEX; ANTERIOR CINGULATE CORTEX; HIPPOCAMPAL VOLUME; AMYGDALA VOLUME; ANATOMICAL MRI; MOOD; PREDICTS; METAANALYSIS; MORPHOMETRY; VARIABILITY;
D O I
10.1016/j.jad.2011.10.038
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Fronto-limbic dysregulation in major depressive disorder (MDD) may be influenced by early life stress and antidepressant treatment. The present structural MRI study aimed to determine the relationship between amygdala, cingulate and subgenual prefrontal cortex volumes in MDD and their associations with child abuse and antidepressants. Methods: Right-handed subjects (21-50 years), meeting DSM-IV criteria for MDD, either with (n =19) or without (n = 20) childhood sexual or physical abuse. Healthy controls (n =34) were matched for age, sex, education and smoking. 3D-MPRAGE images with a spatial resolution of 1.5 mm x 1.0 mm x 1.0 mm were acquired with a Siemens Sonata 1.5T system. Volumes of subgenual prefrontal cortex, amygdala and affective, cognitive, superior and posterior divisions of cingulate cortex were analyzed using DISPLAY software using reliable volumetric protocols. Groups were compared using ANCOVA, with intracranial volume as a covariate. Results: MDD subjects had low cingulate (cognitive division) and high amygdala volumes. Low cingulate volume was related to abuse and treatment history. Amygdala volume was predicted by subgenual prefrontal and cingulate (cognitive division) volumes and the presence of paracingulate cortex. Limitations: This study was cross sectional and the sample size was limited for subgroup and correlational analyses. Summary: Our data suggest that MDD may be associated with alterations in anterior cingulate cortex and amygdala. Morphological variation, early stress and stress-protective factors may contribute to differences in fronto-limbic structures in MDD. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:1104 / 1113
页数:10
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