ALLOSTERIC INHIBITORS TARGET KRAS IN A MUTANT-SPECIFIC MANNER

被引：0
|
作者：
不详
机构：
来源：
CANCER DISCOVERY | 2014年 / 4卷 / 01期
关键词：
D O I：
10.1158/2159-8290.CD-RW2013-260
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：17 / 17
页数：1
相关论文
共 50 条
  • [41] Multi-target, ensemble-based virtual screening yields novel allosteric KRAS inhibitors at high success rate
    Gupta, Amit K.
    Wang, Xu
    Pagba, Cynthia V.
    Prakash, Priyanka
    Sarkar-Banerjee, Suparna
    Putkey, John
    Gorfe, Alemayehu A.
    CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 94 (02) : 1441 - 1456
  • [42] Identification of RNA Aptamer Specific to Mutant KRAS Protein
    Jeong, Sujin
    Han, Seung Ryul
    Lee, Young Ju
    Kim, Ju Hyun
    Lee, Seong-Wook
    OLIGONUCLEOTIDES, 2010, 20 (03) : 155 - 161
  • [43] c-Raf in KRas Mutant Cancers: A Moving Target
    McCormick, Frank
    CANCER CELL, 2018, 33 (02) : 158 - 159
  • [44] Development of siRNA Payloads to Target KRAS-Mutant Cancer
    Yuan, Tina L.
    Fellmann, Christof
    Lee, Chih-Shia
    Ritchie, Cayde D.
    Thapar, Vishal
    Lee, Liam G.
    Hsu, Dennis J.
    Grace, Danielle
    Carver, Joseph O.
    Zuber, Johannes
    Luo, Ji
    McCormick, Frank
    Lowe, Scott W.
    CANCER DISCOVERY, 2014, 4 (10) : 1182 - 1197
  • [45] Mutant-specific mexiletine block of myopathic sodium channels explained by differences in gating.
    Desaphy, JF
    De Luca, A
    Pierno, S
    Lentini, G
    Franchini, C
    Tortorella, V
    George, AL
    Camerino, DC
    BRITISH JOURNAL OF PHARMACOLOGY, 2001, 133 : U115 - U115
  • [46] Intrinsic resistance mechanisms to mutant KRAS specific inhibitor in KRAS mutated colorectal cancer
    Maruyama, Kohei
    Suzuki, Mai
    Ohhara, Tomoko
    Nagayama, Satoshi
    Fujita, Naoya
    Katayama, Ryohei
    CANCER SCIENCE, 2023, 114 : 1210 - 1210
  • [47] Intrinsic resistance mechanisms to mutant KRAS specific inhibitor in KRAS mutated colorectal cancer
    Maruyama, Kohei
    Suzuki, Mai
    Ohhara, Tomoko
    Nagayama, Satoshi
    Fujita, Naoya
    Katayama, Ryohei
    CANCER SCIENCE, 2023, 114 : 783 - 783
  • [48] Inhibitors of the Herbicidal Target IspD: Allosteric Site Binding
    Witschel, Matthias C.
    Hoeffken, H. Wolfgang
    Seet, Michael
    Parra, Liliana
    Mietzner, Thomas
    Thater, Frank
    Niggeweg, Ricarda
    Roehl, Franz
    Illarionov, Boris
    Rohdich, Felix
    Kaiser, Johannes
    Fischer, Markus
    Bacher, Adelbert
    Diederich, Francois
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (34) : 7931 - 7935
  • [49] Use of Mutant-Specific Ion Channel Characteristics for Risk Stratification of Long QT Syndrome Patients
    Jons, Christian
    O-Uchi, Jin
    Moss, Arthur J.
    Reumann, Matthias
    Rice, John J.
    Goldenberg, Ilan
    Zareba, Wojciech
    Wilde, Arthur A. M.
    Shimizu, Wataru
    Kanters, Jorgen K.
    McNitt, Scott
    Hofman, Nynke
    Robinson, Jennifer L.
    Lopes, Coeli M. B.
    SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (76)
  • [50] Update on recent preclinical and clinical studies of T790M mutant-specific irreversible epidermal growth factor receptor tyrosine kinase inhibitors
    Liao, Bin-Chi
    Lin, Chia-Chi
    Lee, Jih-Hsiang
    Yang, James Chih-Hsin
    JOURNAL OF BIOMEDICAL SCIENCE, 2016, 23
12345