Potential applications of nicotinic ligands in the laboratory and clinic

被引：16

作者：

Dani, JA ^{[1
]}

De Biasi, M ^{[1
]}

Liang, Y ^{[1
]}

Peterson, J ^{[1
]}

Zhang, L ^{[1
]}

Zhang, T ^{[1
]}

Zhou, FM ^{[1
]}

机构：

[1] Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 08期

关键词：

D O I：

10.1016/j.bmcl.2003.07.036

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The nicotinic acetylcholine receptor (nAChR) is a receptor, ion channel complex composed of five polypeptide subunits. There are many different nAChR subtypes constructed from a variety of different subunit combinations. This structural diversity contributes to the varied roles of nAChRs in the peripheral and central nervous system, and this diversity offers an excellent opportunity for chemists who are producing ligands. Subunit specific ligands could have wide and varied effects in the laboratory as experimental tools and in the clinic as therapeutic agents. Because presynaptic nAChRs have been shown to enhance the release of many neurotransmitters, new nicotinic ligands that potentiate nAChR activity would be very useful. Such ligands could enhance the release of various neurotransmitters during degenerative diseases that cause neurotransmitter systems to decrease their output. For example, boosting the release from cholinergic neurons would help patients with Alzheimer's disease, and boosting the release from dopaminergic neurons would help patients with Parkinson's disease. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1837 / 1839

页数：3

共 31 条

[1]

Albuquerque EX, 1997, J PHARMACOL EXP THER, V280, P1117

[2] UNCONVENTIONAL PHARMACOLOGY OF A NEURONAL NICOTINIC RECEPTOR MUTATED IN THE CHANNEL DOMAIN [J].