Preventing Bacterial Suicide: A Novel Toxin-Antitoxin Strategy

被引：27
|
作者：
Markovski, Monica [1 ]
Wickner, Sue [1 ]
机构：
[1] NCI, Mol Biol Lab, Bethesda, MD 20892 USA
来源：
MOLECULAR CELL | 2013年 / 52卷 / 05期
关键词：
REPLICATION; SYSTEMS;
D O I：
10.1016/j.molcel.2013.11.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this issue of Molecular Cell, Aarke et al. (2013) identify a toxin-antitoxin system in Caulobacter crescentus that acts by a unique mechanism. The toxin, which blocks DNA replication, is constitutively degraded by CIpXP, and this degradation requires the antitoxin, a CIpXP adaptor.
引用
收藏
页码：611 / 612
页数：2
相关论文
共 50 条
  • [1] Ribonucleases in bacterial toxin-antitoxin systems
    Cook, Gregory M.
    Robson, Jennifer R.
    Frampton, Rebekah A.
    McKenzie, Joanna
    Przybilski, Rita
    Fineran, Peter C.
    Arcus, Vickery L.
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2013, 1829 (6-7): : 523 - 531
  • [2] Bacterial Persistence and Toxin-Antitoxin Loci
    Gerdes, Kenn
    Maisonneuve, Etienne
    ANNUAL REVIEW OF MICROBIOLOGY, VOL 66, 2012, 66 : 103 - 123
  • [3] Toxin-antitoxin systems in bacterial pathogenesis
    Sonika, Sonika
    Singh, Samer
    Mishra, Saurabh
    Verma, Shashikala
    HELIYON, 2023, 9 (04)
  • [4] A novel widespread toxin-antitoxin module
    Piscotta, Frank
    Link, A. James
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
  • [5] Toxin-antitoxin systems: novel mechanisms of toxin activity and antitoxin inhibition
    Page, Rebecca
    Peti, Wolfgang
    FASEB JOURNAL, 2017, 31
  • [6] Bacterial type I toxin-antitoxin systems
    Brantl, Sabine
    RNA BIOLOGY, 2012, 9 (12) : 1488 - 1490
  • [7] Biology and evolution of bacterial toxin-antitoxin systems
    Jurenas, Dukas
    Fraikin, Nathan
    Goormaghtigh, Frederic
    Van Melderen, Laurence
    NATURE REVIEWS MICROBIOLOGY, 2022, 20 (06) : 335 - 350
  • [8] Toxin-Antitoxin Systems and Bacterial Persistence (Review)
    Zamakhaev, M., V
    Goncharenko, A., V
    Shumkov, M. S.
    APPLIED BIOCHEMISTRY AND MICROBIOLOGY, 2019, 55 (06) : 571 - 581
  • [9] Progress in the study of bacterial toxin-antitoxin system
    Wang Xiao-Lei
    Zhao Long-Xuan
    Zhang Jun-Jie
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2008, 35 (09) : 991 - 997
  • [10] TASmania: A bacterial Toxin-Antitoxin Systems database
    Akarsu, Hatice
    Bordes, Patricia
    Mansour, Moise
    Bigot, Donna-Joe
    Genevaux, Pierre
    Falquet, Laurent
    PLOS COMPUTATIONAL BIOLOGY, 2019, 15 (04)
12345