Novel therapeutic approach with PAC-14028 cream, a TRPV1 antagonist, for patients with mild-to-moderate atopic dermatitis

被引：12
作者：
Song, P. I. [1 ]
Armstrong, C. A. [2 ]
机构：
[1] Univ Colorado, Dept Dermatol, Denver Sch Med, Aurora, CO 80045 USA
[2] Denver Hlth Med Ctr, Div Dermatol, Denver, CO 80204 USA
来源：
BRITISH JOURNAL OF DERMATOLOGY | 2019年 / 180卷 / 05期
关键词：
D O I：
10.1111/bjd.17777
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Linked Article: Lee et al. Br J Dermatol 2019; 180: 1030-1038.
引用
收藏
页码：971 / 972
页数：2
相关论文
共 10 条
[1]   Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis [J].
Assas, Bakri M. ;
Pennock, Joanne I. ;
Miyan, Jaleel A. .
FRONTIERS IN NEUROSCIENCE, 2014, 8
[2]   A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1 [J].
Cevikbas, Ferda ;
Wang, Xidao ;
Akiyama, Tasuku ;
Kempkes, Cordula ;
Savinko, Terhi ;
Antal, Attila ;
Kukova, Gabriela ;
Buhl, Timo ;
Ikoma, Akihiko ;
Buddenkotte, Joerg ;
Soumelis, Vassili ;
Feld, Micha ;
Alenius, Harri ;
Dillon, Stacey R. ;
Carstens, Earl ;
Homey, Bernhard ;
Basbaum, Allan ;
Steinhoff, Martin .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 133 (02) :448-+
[3]   TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms [J].
Imamachi, Noritaka ;
Park, Goon Ho ;
Lee, Hyosang ;
Anderson, David J. ;
Simon, Melvin I. ;
Basbaum, Allan I. ;
Han, Sang-Kyou .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (27) :11330-11335
[4]  
Lee JH, 2018, J DERMATOL SCI
[5]   Efficacy and safety of PAC-14028 cream - a novel, topical, nonsteroidal, selective TRPV1 antagonist in patients with mild-to-moderate atopic dermatitis: a phase IIb randomized trial [J].
Lee, Y. W. ;
Won, C. -H. ;
Jung, K. ;
Nam, H. -J. ;
Choi, G. ;
Park, Y. -H. ;
Park, M. ;
Kim, B. .
BRITISH JOURNAL OF DERMATOLOGY, 2019, 180 (05) :1030-1038
[6]   Development of PAC-14028, a Novel Transient Receptor Potential Vanilloid Type 1 (TRPV1) Channel Antagonist as a New Drug for Refractory Skin Diseases [J].
Lim, Kyung-Min ;
Park, Young-Ho .
ARCHIVES OF PHARMACAL RESEARCH, 2012, 35 (03) :393-396
[7]   Ethanol causes neurogenic vasodilation by TRPV1 activation and CGRP release in the trigeminovascular system of the guinea pig [J].
Nicoletti, P. ;
Trevisani, M. ;
Manconi, M. ;
Gatti, R. ;
De Siena, G. ;
Zagli, G. ;
Benemei, S. ;
Capone, J. A. ;
Geppetti, P. ;
Pini, L. A. .
CEPHALALGIA, 2008, 28 (01) :9-17
[8]   Emerging Treatment Options in Atopic Dermatitis: Topical Therapies [J].
Nygaard, Uffe ;
Deleuran, Mette ;
Vestergaard, Christian .
DERMATOLOGY, 2017, 233 (05) :333-343
[9]   Antipruritic Effects of TRPV1 Antagonist in Murine Atopic Dermatitis and Itching Models [J].
Yun, Jun-Won ;
Seo, Jung A. ;
Jang, Won-Hee ;
Koh, Hyun Ju ;
Bae, Il-Hong ;
Park, Young-Ho ;
Lim, Kyung-Min .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (07) :1576-1579
[10]   TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery [J].
Yun, Jun-Won ;
Seo, Jung A. ;
Jeong, Yeon Su ;
Bae, Il-Hong ;
Jang, Won-Hee ;
Lee, Jihae ;
Kim, Sun-Young ;
Shin, Song-Seok ;
Woo, Byoung-Young ;
Lee, Ki-Wha ;
Lim, Kyung-Min ;
Park, Young-Ho .
JOURNAL OF DERMATOLOGICAL SCIENCE, 2011, 62 (01) :8-15
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